Neuroradiology

, Volume 50, Issue 10, pp 849–853 | Cite as

Assessment of intima-media thickness of carotid arteries: evaluation of an automated computer software

  • Stefan Puchner
  • Markus Reiter
  • Christos Baros
  • Erich Minar
  • Johannes Lammer
  • Robert A. Bucek
Diagnostic Neuroradiology

Abstract

Introduction

The aim of this study was to evaluate the feasibility and accuracy of commercially available software directly implemented on the ultrasound scanner for automated measurement of the intima-media thickness (IMT) of the common carotid artery on source images.

Materials and methods

Measurements were performed on a GE Vivid 3 ultrasound scanner. First, inter- and intraobserver correlations were assessed for the automated and the manual measurements. Second, the correlation between automated and manual measurements was assessed in 199 asymptomatic patients with a mean age of 30 years (range 20–41 years).

Results

The measurement was feasible in all patients and a standard configuration with optimum quality was determined. The inter- and intraobserver correlations obtained using the automated software were excellent and slightly inferior to the manual measurements. The correlation of the automated and manual measurements was significant (r = 0.86; P < 0.01) and the mean difference between both measurements was low (0.023 ± 0.034 mm).

Conclusions

The software allowed an efficient and quick measurement by providing at the same time comparable results to the manual measurement and a better inter- and intraobserver variability.

Keywords

Intima-media thickness Sonography Carotid Automated Computer software 

Notes

Conflict of interest statement

We declare that we have no conflict of interest.

References

  1. 1.
    Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE (1997) Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 96:1432–1437PubMedGoogle Scholar
  2. 2.
    Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, Azen SP (1998) The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 128:262–269PubMedGoogle Scholar
  3. 3.
    Salonen JT, Salonen R (1993) Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 87(3 Suppl):II56–65 ReviewPubMedGoogle Scholar
  4. 4.
    Burke GL, Evans GW, Riley WA, Sharrett AR, Howard G, Barnes RW, Rosamond W, Crow RS, Rautaharju PM, Heiss G (1995) Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 26:386–391PubMedGoogle Scholar
  5. 5.
    Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX (1997) Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 146:483–494PubMedGoogle Scholar
  6. 6.
    Bots ML, Hofman A, de Bruyn AM, de Jong PT, Grobbee DE (1993) Isolated systolic hypertension and vessel wall thickness of the carotid artery. The Rotterdam Elderly Study. Arterioscler Thromb 13:64–69Google Scholar
  7. 7.
    Persson J, Israelsson B, Stavenow L, Holmstrom E, Berglund G (1996) Progression of atherosclerosis in middle-aged men: effects of multifactorial intervention. J Intern Med 239:425–433PubMedCrossRefGoogle Scholar
  8. 8.
    Schmidt C, Wendelhag I (1999) How can the variability in ultrasound measurement of intima-media thickness be reduced? Studies of interobserver variability in carotid and femoral arteries. Clin Physiol 19:45–55PubMedCrossRefGoogle Scholar
  9. 9.
    Wendelhag I, Wiklund O, Wikstrand J (1996) On quantifying plaque size and intima-media thickness in carotid and femoral arteries. Comments on results from a prospective ultrasound study in patients with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 16:843–850PubMedGoogle Scholar
  10. 10.
    Wendelhag I, Gustavsson T, Suurkula M, Berglund G, Wikstrand J (1991) Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of a computerized analysing system. Clin Physiol 11:565–577 ReviewPubMedCrossRefGoogle Scholar
  11. 11.
    Wendelhag I, Liang Q, Gustavsson T, Wikstrand J (1997) A new automated computerized analyzing system simplifies readings and reduces the variability in ultrasound measurement of intima-media thickness. Stroke 28:2195–2200PubMedGoogle Scholar
  12. 12.
    Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Desvarieux M, Ebrahim S, Fatar M, Hernandez Hernandez R, Kownator S, Prati P, Rundek T, Taylor A, Bornstein N, Csiba L, Vicaut E, Woo KS, Zannad F (2004) Advisory Board of the 3rd Watching the Risk Symposium 2004, 13th European Stroke Conference. Mannheim intima-media thickness consensus. Cerebrovasc Dis 18:346–349PubMedCrossRefGoogle Scholar
  13. 13.
    Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M, Hernandez Hernandez R, Jaff M, Kownator S, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS, Zannad F, Zureik M (2007) Mannheim carotid intima-media thickness consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 23:75–80PubMedCrossRefGoogle Scholar
  14. 14.
    Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307–310PubMedGoogle Scholar
  15. 15.
    Bland JM, Altman DG (1999) Measuring agreement in method comparison studies. Stat Methods Med Res 8:135–160 ReviewPubMedCrossRefGoogle Scholar
  16. 16.
    Selzer RH, Mack WJ, Lee PL, Kwong-Fu H, Hodis HN (2001) Improved common carotid elasticity and intima-media thickness measurements from computer analysis of sequential ultrasound frames. Atherosclerosis 154:185–193PubMedCrossRefGoogle Scholar
  17. 17.
    Loizou CP, Pattichis CS, Pantziaris M, Tyllis T, Nicolaides A (2007) Snakes based segmentation of the common carotid artery intima media. Med Biol Eng Comput 45:35–49PubMedCrossRefGoogle Scholar
  18. 18.
    Loizou CP, Pattichis CS, Pantziaris M, Nicolaides A (2007) An integrated system for the segmentation of atherosclerotic carotid plaque. IEEE Trans Inf Technol Biomed 11:661–667PubMedCrossRefGoogle Scholar
  19. 19.
    Loizou CP, Pattichis CS, Christodoulou CI, Istepanian RS, Pantziaris M, Nicolaides A (2005) Comparative evaluation of despeckle filtering in ultrasound imaging of the carotid artery. IEEE Trans Ultrason Ferroelectr Freq Control 52:1653–1669PubMedCrossRefGoogle Scholar
  20. 20.
    Elatrozy T, Nicolaides A, Tegos T, Zarka AZ, Griffin M, Sabetai M (1998) The effect of B-mode ultrasonic image standardisation on the echodensity of symptomatic and asymptomatic carotid bifurcation plaques. Int Angiol 17:179–186PubMedGoogle Scholar
  21. 21.
    Stein JH, Korcarz CE, Mays ME, Douglas PS, Palta M, Zhang H, Lecaire T, Paine D, Gustafson D, Fan L (2005) A semiautomated ultrasound border detection program that facilitates clinical measurement of ultrasound carotid intima-media thickness. J Am Soc Echocardiogr 18:244–251PubMedCrossRefGoogle Scholar
  22. 22.
    van Dam MJ, de Groot E, Clee SM, Hovingh GK, Roelants R, Brooks-Wilson A, Zwinderman AH, Smit AJ, Smelt AH, Groen AK, Hayden MR, Kastelein JJ (2002) Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study. Lancet 359:37–42PubMedCrossRefGoogle Scholar
  23. 23.
    Seçil M, Altay C, Gülcü A, Ceçe H, Göktay AY, Dicle O (2005) Automated measurement of intima-media thickness of carotid arteries in ultrasonography by computer software. Diagn Interv Radiol 11:105–108PubMedGoogle Scholar
  24. 24.
    Kanters SD, Algra A, van Leeuwen MS, Banga JD (1997) Reproducibility of in vivo carotid intima-media thickness measurements: a review. Stroke 28:665–671 ReviewPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Stefan Puchner
    • 1
  • Markus Reiter
    • 1
  • Christos Baros
    • 1
  • Erich Minar
    • 2
  • Johannes Lammer
    • 1
  • Robert A. Bucek
    • 1
  1. 1.Department of Cardiovascular and Interventional Radiology, General HospitalMedical University ViennaViennaAustria
  2. 2.Department of Angiology, General HospitalMedical University ViennaViennaAustria

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