, Volume 50, Issue 4, pp 293–299

Diffusion abnormalities of the uncinate fasciculus in Alzheimer’s disease: diffusion tensor tract-specific analysis using a new method to measure the core of the tract

  • Hasina Yasmin
  • Yasuhiro Nakata
  • Shigeki Aoki
  • Osamu Abe
  • Noriko Sato
  • Kiyotaka Nemoto
  • Kunimasa Arima
  • Nobuo Furuta
  • Masatake Uno
  • Shigeo Hirai
  • Yoshitaka Masutani
  • Kuni Ohtomo
Diagnostic Neuroradiology



Our aim was to determine diffusion abnormalities in the uncinate fasciculus (UF) in Alzheimer’s disease (AD) by diffusion tensor tractography (DTT) using a new method for measuring the core of the tract.


We studied 19 patients with AD and 19 age-matched control subjects who underwent MRI using diffusion tensor imaging (DTI). DTT of the UF was generated. The mean diffusivity (MD) and fractional anisotropy (FA) of the core of the tract were measured after voxelized tract shape processing. Student’s t-test was used to compare results between patients with AD and controls. Intraobserver correlation tests were also performed.


FA was significantly lower (P < 0.0001) in the UF of patients with AD than of controls. There was no significant difference in MD along the UF between the two groups. Intraobserver reliability (intraclass correlation coefficient) for the first and second measurement was r > 0.93 for measured FA and r > 0.92 for measured MD.


Our results suggest that FA reflects progression of AD-related histopathological changes in the UF of the white matter and may represent a useful biological index in monitoring AD. Diffusion tensor tract-specific analysis with voxelized tract shape processing to measure the core of the tract may be a sensitive tool for evaluation of diffusion abnormalities of white matter tracts in AD.


Alzheimer’s disease Uncinate fasciculus Diffusion tensor imaging Diffusion tensor tractography Tract-specific analysis 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Hasina Yasmin
    • 1
  • Yasuhiro Nakata
    • 1
  • Shigeki Aoki
    • 1
    • 1
  • Osamu Abe
    • 1
  • Noriko Sato
    • 2
  • Kiyotaka Nemoto
    • 3
  • Kunimasa Arima
    • 4
  • Nobuo Furuta
    • 4
  • Masatake Uno
    • 5
  • Shigeo Hirai
    • 6
  • Yoshitaka Masutani
    • 1
  • Kuni Ohtomo
    • 1
  1. 1.Department of RadiologyUniversity of TokyoTokyoJapan
  2. 2.Department of Radiology, National Center Hospital for Mental, Nervous and Muscular DisordersNational Center of Neurology and PsychiatryTokyoJapan
  3. 3.Department of PsychiatryIbaraki Prefectural Tomobe HospitalIbarakiJapan
  4. 4.Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular DisordersNational Center of Neurology and PsychiatryTokyoJapan
  5. 5.Department of PsychiatryYoshioka Rehabilitation ClinicTokyoJapan
  6. 6.Department of PsychiatryIruma Hirai ClinicSaitamaJapan

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