Clinical applications of diffusion tensor tractography of the spinal cord
- 896 Downloads
Diffusion tensor imaging (DTI) can visualize the white matter tracts in vivo. The aim of this study was to assess the clinical utility of DTI in patients with diseases of the spinal cord. Fourteen subjects underwent magnetic resonance imaging of the spine at 1.5 T. Preliminary diagnosis of the patients suggested traumatic, tumorous, ischemic or inflammatory lesions of the spinal cord. In addition to T2-weighted images, DTI was performed with the gradients in 30 orthogonal directions. Maps of the apparent diffusion coefficient and of fractional anisotropy were reconstructed. Diffusion tensor imaging showed a clear displacement and deformation of the white matter tracts at the level of the pathological lesions in the spinal cord. This capability of diffusion tensor imaging to reliably display secondary alterations to the white matter tracts caused by the primary lesion has the potential to be of great utility for treatment planning and follow-up.
KeywordsDiffusion Diffusion tensor imaging Magnetic resonance imaging Spinal cord Spine
Conflict of interest statement
We declare that we have no conflict of interest.
The authors thank Stefan Huwer and Heiko Maier from the Siemens Advanced Neuro MR development group in Erlangen for helpful discussions and collaboration of the Neuro3D software.
- 8.Ducreux D, Lepeintre JF, Fillard P, Loureiro C, Tadie M, Lasjaunias P (2006) MR diffusion tensor imaging and fiber tracking in 5 spinal cord astrocytomas. Am J Neuroradiol 2006 27(1):214–216Google Scholar