, Volume 50, Issue 1, pp 57–65

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils

  • Aquilla S. Turk
  • Christopher M. Luty
  • Victoria Carr-Brendel
  • Igor Polyakov
  • Dan Consigny
  • Julie Grinde
  • Rajat Mukherjee
  • Charles M. Strother
Interventional Neuroradiology



It is claimed that bioactive coils induce accelerated and more durable aneurysm healing. Data supporting this claim are quite limited. Our purpose was to compare the angiographic and histological results obtained following treatment with different coil types.


Bifurcation type aneurysms were surgically created in 24 dogs and treated using standard clinical techniques. Eight were treated with Guglielmi detachable coils (GDC), eight with first-generation Matrix coils, and eight with a combination of GDC and Matrix coils. The aneurysms were explanted and final angiographic evaluations performed 12 weeks after treatment. Angiographic and histological outcomes were documented.


Increased coil compaction with aneurysm recurrence was found in aneurysms treated with first-generation Matrix coils as compared to standard GDC (P = 0.0001). In aneurysms treated with first-generation Matrix coils thrombus organization was better than in those treated with either standard GDC coils (P = 0.008) or with a combination of GDC and Matrix coils (P = 0.04). In aneurysms treated with first-generation Matrix coils there were no endothelialized vascular clefts within the coil mass, but they were seen in the majority of aneurysms treated with GDC or a combination of GDC and Matrix coils (P = 0.003).


Aneurysms treated with first-generation Matrix coils showed the greatest degree of coil compaction and aneurysm recurrence on the final angiographic evaluation. Aneurysms treated with first-generation Matrix coils showed enhanced thrombus organization and absence of vascular clefts at the aneurysm neck that were markedly different from those treated with bare platinum coils or a combination of GDC and Matrix coils.


Animal model Aneurysm Coils 


  1. 1.
    Molyneux A, Kerr R, Stratton I, Sandercock P, Clarke M, Shrimpton J, Holman R; International Subarachnoid Aneurysm Trial (ISAT) Collaboration Group (2002) International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet 360(9342):1267–1274CrossRefGoogle Scholar
  2. 2.
    Raymond J, Guilbert F, Weill A, Georganos SA, Juravsky L, Lambert A, Lamoureux J, Chagnon M, Roy D (2003) Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke 34(6):1398–1403PubMedCrossRefGoogle Scholar
  3. 3.
    Vinuela F, Duckwiler G, Mawad M (1997) Guglielmi detachable coil embolization of acute intracranial aneurysm: perioperative anatomical and clinical outcome in 403 patients. J Neurosurg 86:475–482PubMedGoogle Scholar
  4. 4.
    Fernandez Zubillaga A, Guglielmi G, Vinuela F, Duckwiler GR (1994) Endovascular occlusion of intracranial aneurysms with electrically detachable coils: correlation of aneurysm neck size and treatment results. AJNR Am J Neuroradiol 15:815–820PubMedGoogle Scholar
  5. 5.
    Malisch TW, Guglielmi G, Vinuela F, Duckwiler G, Gobin YP, Martin NA, Frazee JG (1997) Intracranial aneurysms treated with the Guglielmi detachable coil: midterm clinical results in a consecutive series of 100 patients. J Neurosurg 87:176–183PubMedGoogle Scholar
  6. 6.
    Bavinzski G, Talazoglu V, Killer M, Richling B, Gruber A, Gross CE, Plenk H Jr (1999) Gross and microscopic histopathological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg 91:284–293PubMedGoogle Scholar
  7. 7.
    Szikora I, Seifert P, Hanzely Z, Kulcsar Z, Berentei Z, Marosfoi M, Czirjak S, Vajda J, Nyary I (2006) Histopathologic evaluation of aneurysms treated with Guglielmi detachable coils or Matrix detachable microcoils. AJNR Am J Neuroradiol 27(2):283–288PubMedGoogle Scholar
  8. 8.
    Ding YH, Dai D, Lewis DA, Cloft HJ, Kallmes DF (2005) Angiographic and histologic analysis of experimental aneurysms embolized with platinum coils, Matrix and HydroCoil. AJNR Am J Neuroradiol 26:1757–1763PubMedGoogle Scholar
  9. 9.
    Raymond J, Guilbert F, Metcalfe A, Gevry G, Salazkin I, Robledo O (2004) Role of the endothelial lining in recurrences after coil embolization: prevention of recanalization by endothelial denudation. Stroke 35(6):1471–1475PubMedCrossRefGoogle Scholar
  10. 10.
    Mawad ME, Mawad JK, Cartwright J, Gokaslan Z (1995) Long-term histopathological changes in canine aneurysms embolized with Guglielmi detachable coils. AJNR Am J Neuroradiol 16:7–13PubMedGoogle Scholar
  11. 11.
    Reul J, Weis J, Spetzger U, Konert T, Fricke C, Thron A (1997) Long-term angiographic and histopathologic findings in experimental aneurysms of the carotid bifurcation embolized with platinum and tungsten coils. AJNR Am J Neuroradiol 18:35–42PubMedGoogle Scholar
  12. 12.
    Raymond J, Leblanc P, Morel F, Salazkin I, Gevry G, Roorda S (2003) Beta radiation and inhibition of recanalization after coil embolization of canine arteries and experimental aneurysms: how should radiation be delivered? Stroke 34(5):1262–1268PubMedCrossRefGoogle Scholar
  13. 13.
    Ahuja AA, Hergenrother RW, Strother CM, Rappe AA, Cooper SL, Graves VB (1993) Platinum coil coatings to increase thrombogenicity: a preliminary study in rabbits. AJNR Am J Neuroradiol 14:794–798PubMedGoogle Scholar
  14. 14.
    Szikora I, Wakhloo AK, Guterman LR, Chavis TD, Dawson RC 3rd, Hergenrother RW, Twyford RH, Hopkins LN (1997) Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms. AJNR Am J Neuroradiol 18:667–672PubMedGoogle Scholar
  15. 15.
    Dawson RC, Krisht AF, Barrow DL, Joseph GJ, Shengelaia GG, Bonner G (1995) Treatment of experimental aneurysms using collagen-coated microcoils. Neurosurgery 36:133–140PubMedCrossRefGoogle Scholar
  16. 16.
    Kallmes DF, Williams AD, Cloft HJ, Lopes MBS, Hankins GR, Helm GA (1998) Platinum coil-mediated implantation of growth factor-secreting endovascular tissue grafts: an in vivo study. Radiology 207:519–523PubMedGoogle Scholar
  17. 17.
    Venne D, Raymond J, Allas S, Roy D, Leclerc G, Boushria M, Brazeau P (1999) Healing of experimental aneurysms. II: Platelet extracts can increase the thickness of the neointima at the neck of treated aneurysms. J Neuroradiol 26:92–100PubMedGoogle Scholar
  18. 18.
    Murayama Y, Vinuela F, Suzuki Y, Do HM, Massoud TF, Guglielmi G, Ji C, Iwaki M, Kusakabe M, Kamio M, Abe T (1997) Ion implantation and protein coating of detachable coils for endovascular treatment of cerebral aneurysms: concepts and preliminary results in a swine model. Neurosurgery 40:1233–1244PubMedCrossRefGoogle Scholar
  19. 19.
    Murayama Y, Vinuela F, Suzuki Y, Akiba Y, Ulihoa A, Duckwiler GR, Gobin YP, Vinters HV, Iwaki M, Abe T (1999) Development of the biologically active Guglielmi detachable coil for the treatment of cerebral aneurysms. Part II: an experimental study in a swine aneurysm model. AJNR Am J Neuroradiol 20:1992–1999PubMedGoogle Scholar
  20. 20.
    de Gast AN, Altes TA, Marx WF, Do HM, Helm GA, Kallmes DF (2001) Transforming growth factor beta-coated platinum coils for endovascular treatment of aneurysms: an animal study. Neurosurgery 49(3):690–694PubMedCrossRefGoogle Scholar
  21. 21.
    Dai D, Ding YH, Danielson MA (2007) Endovascular treatment of experimental aneurysms by use of fibroblast-coated platinum coils: an angiographic and histopathologic study. Stroke 38(1):170–176PubMedCrossRefGoogle Scholar
  22. 22.
    German WJ, Black SPW (1954) Experimental production of carotid aneurysms. New Engl J Med 3:463–468Google Scholar
  23. 23.
    Raymond J, Roy D, Bojanowski M, Moumdjian R, L’Esperance G (1997) Endovascular treatment of acutely ruptured and unruptured aneurysms of the basilar bifurcation. J Neurosurg 86:211–219PubMedCrossRefGoogle Scholar
  24. 24.
    Murayama Y, Nien YL, Duckwiler G, Gobin YP, Jahan R, Frazee J, Martin N, Vinuela F (2003) Guglielmi detachable coil embolization of cerebral aneurysms: 11 years’ experience. J Neurosurg 98(5):959–966PubMedGoogle Scholar
  25. 25.
    Turk AS, Aagaard-Kienitz B, Niemann DB, Consigny D, Rappe A, Grinde J, Strother CM (2007) Natural history of the canine vein pouch aneurysm model. AJNR Am J Neuroradiol 28(3):531–532PubMedGoogle Scholar
  26. 26.
    Strother CM, Graves VB, Rappe AA (1992) Aneurysm hemodynamics: an experimental model. AJNR Am J Neuroradiol 13:1089–1095PubMedGoogle Scholar
  27. 27.
    Fiorella D, Albuquerque FC, McDougall CG (2006) Durability of aneurysm embolization with Matrix detachable coils. Neurosurgery 58(1):51–59PubMedCrossRefGoogle Scholar
  28. 28.
    Niimi Y, Song J, Madrid M, Berenstein A (2006) Endosaccular treatment of intracranial aneurysms using Matrix coils: early experience and midterm follow-up. Stroke 37(4):1028–1032PubMedCrossRefGoogle Scholar
  29. 29.
    Murayama Y, Tateshima S, Gonzalez NR, Vinuela F (2003) Matrix and bioabsorbable polymeric coils accelerate healing of intracranial aneurysms: long-term experimental study. Stroke 34(8):2031–2037PubMedCrossRefGoogle Scholar
  30. 30.
    Linfante I, Akkawi NM, Perlow A, Andreone V, Wakhloo AK (2005) Polyglycolide/polylactide-coated platinum coils for patients with ruptured and unruptured cerebral aneurysms: a single-center experience. Stroke 36(9):1948–1953PubMedCrossRefGoogle Scholar
  31. 31.
    Taschner CA, Leclerc X, Rachdi H, Barros AM, Pruvo JP (2005) Matrix detachable coils for the endovascular treatment of intracranial aneurysms. Stroke 36:2176–2180PubMedCrossRefGoogle Scholar
  32. 32.
    Murayama Y, Vinuela F, Ishii A, Nien YL, Yuki I, Duckwiler G, Jahan R (2006) Initial clinical experience with Matrix detachable coils for the treatment of intracranial aneurysms. J Neurosurg 105(2):192–199PubMedGoogle Scholar
  33. 33.
    Song JK, Niimi Y, Yoshino Y, Khoyama S, Berenstein A (2007) Assessment of Matrix coils in a canine model of a large bifurcation aneurysm. Neuroradiology 49:231–235PubMedCrossRefGoogle Scholar
  34. 34.
    Kai Y, Hamada J, Morioka M, Yano S, Kuratsu J (2005) Evaluation of the stability of small ruptured aneurysms with a small neck after embolization with Guglielmi detachable coils: correlation between coil packing ratio and coil compaction. Neurosurgery 56(4):785–792PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Aquilla S. Turk
    • 1
    • 2
  • Christopher M. Luty
    • 4
  • Victoria Carr-Brendel
    • 5
  • Igor Polyakov
    • 5
  • Dan Consigny
    • 1
  • Julie Grinde
    • 1
  • Rajat Mukherjee
    • 3
  • Charles M. Strother
    • 1
  1. 1.Department of RadiologyUniversity of Wisconsin Hospital and ClinicsMadisonUSA
  2. 2.Department of NeurosurgeryUniversity of Wisconsin Hospital and ClinicsMadisonUSA
  3. 3.Department of StatisticsUniversity of Wisconsin Hospital and ClinicsMadisonUSA
  4. 4.University of Wisconsin School of Medicine and Public HealthMadisonUSA
  5. 5.Neurovascular DivisionBoston Scientific CorporationFremontUSA

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