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Neuroradiology

, Volume 49, Issue 3, pp 203–209 | Cite as

Neuroradiologic characteristics of astroblastoma

  • John W. BellEmail author
  • Anne G. Osborn
  • Karen L. Salzman
  • Susan I. Blaser
  • Blaise V. Jones
  • Steven S. Chin
Diagnostic Neuroradiology

Abstract

Introduction

Astroblastoma is a rare glial tumor of uncertain origin. Only a few scattered case reports and one small case series have described the radiologic appearance of this uncommon tumor. Many features previously identified are similar to those of other primary malignant brain tumors. We report the largest imaging series to date and further delineate the CT and MRI features of astroblastoma. We identify those features that may be useful in distinguishing astroblastoma from other neoplasms.

Methods

The radiologic images, pathology reports, and clinical information of 12 patients with pathology-confirmed astroblastoma were retrospectively reviewed. CT and MRI findings including location, morphology, signal intensity, and presence and patterns of enhancement were tabulated.

Results

Patients ranged in age from 0 (newborn) to 50 years with a mean of 20 years at the time of initial diagnosis. A striking female preponderance (11:1) was found. All tumors were supratentorial. There were multiple intratumoral cysts in 7 (58%) of the 12 patients. Nine (75%) showed strong rim enhancement and 3 (25%) showed no rim enhancement.

Conclusion

The imaging features of astroblastoma are identified in 12 previously unreported cases. Distinguishing features that can be used to narrow the differential diagnosis with more common primary brain neoplasms reflect a combination of age, anatomic location, and specific imaging findings such as demarcation, heterogeneous tumor enhancement, rim enhancement, and a multicystic “bubbly” appearance. Intraventricular location, intratumoral hemorrhage with a fluid-fluid level, and dural “tails” are less common but important additions to the imaging spectrum.

Keywords

Astroblastoma Primary brain neoplasm Glial tumor Imaging characteristics 

Notes

Conflict of interest statement

We declare that we have no conflict of interest.

References

  1. 1.
    Scharenberg K, Liss L (1969) Neuroectodermal tumors of the central and peripheral nervous system. Williams & Wilkins, Baltimore, pp 17–29Google Scholar
  2. 2.
    Bergstrand H (1932) Über das sog. Astrocytom in Keinhirn. Virchows Arch A Pathol Anat Histopathol 287:538–548Google Scholar
  3. 3.
    Bailey P, Bucy PC (1930) Astroblastomas of the brain. Acta Psychiat Neurol Scand 5:439–461Google Scholar
  4. 4.
    Baka J, Patel S, Roebuck J (1993) Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. AJNR Am J Neuroradiol 14:946–950PubMedGoogle Scholar
  5. 5.
    Sener R (2002) Astroblastoma: diffusion MRI and proton MR spectroscopy. Comput Med Imaging Graph 26:187–191PubMedCrossRefGoogle Scholar
  6. 6.
    Cabrera-Zubizarreta A, Caton B, Martinez de Guerenu B, Larena-Iturbe JA, Ontanon JM, Catalan-Urribarrena G (2002) Low grade astroblastoma: pathological and magnetic resonance findings. Rev Neurol 34:936–939PubMedGoogle Scholar
  7. 7.
    Port J, Brat D, Burger C, Pomper M (2002) Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. AJNR Am J Neuroradiol 23:243–247Google Scholar
  8. 8.
    Kleihues P, Cavenee WK (2000) World Health Organization classification of tumor pathology and genetics of tumors of the central nervous system. IARC Press, LyonGoogle Scholar
  9. 9.
    Bonnin J, Rubinstein L (1989) Astroblastomas: a pathological study of 23 tumors, with a postoperative follow-up in 13 patients. Neurosurgery 25:6–13PubMedCrossRefGoogle Scholar
  10. 10.
    Navarro R, Reitman A, Guillarmo A (2005) Astroblastoma in childhood: pathological and clinical analysis. Childs Nerv Syst 21:211–220PubMedCrossRefGoogle Scholar
  11. 11.
    Thiessen B, Finlay J, Kulkarni R, Rosenblum MK (1998) Astroblastoma: does histology predict biologic behavior? J Neurooncol 40:59–65PubMedCrossRefGoogle Scholar
  12. 12.
    Osborn A, Blaser S, Salzman K, et al (2004) Diagnostic imaging, brain. Amirsys, Salt Lake City, pp 16–100Google Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • John W. Bell
    • 1
    Email author
  • Anne G. Osborn
    • 1
  • Karen L. Salzman
    • 1
  • Susan I. Blaser
    • 2
  • Blaise V. Jones
    • 3
  • Steven S. Chin
    • 4
  1. 1.Department of RadiologyUniversity of UtahSalt Lake CityUSA
  2. 2.Department of Diagnostic RadiologyThe Hospital for Sick ChildrenTorontoCanada
  3. 3.Department of RadiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  4. 4.Department of PathologyUniversity of UtahSalt Lake CityUSA

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