, Volume 47, Issue 11, pp 805–808

Cortical T2 signal shortening in amyotrophic lateral sclerosis is not due to iron deposits

  • M. J. Hecht
  • C. Fellner
  • A. Schmid
  • B. Neundörfer
  • F. A. Fellner
Diagnostic Neuroradiology


Signal shortening of the motor cortex in T2-weighted MR images is a frequent finding in patients with amyotrophic lateral sclerosis (ALS). The cause of signal shortening in ALS is unknown, although iron deposits have been suggested. To test this hypothesis, we acquired T2*-weighted gradient-echo (GRE) MR images in addition to T2-weighted turbo spin-echo in 69 patients with ALS. Signal shortening in T2-weighted images was found in 31 patients. In T2*-weighted GRE images, only three patients had signal shortening. One patient with additional bifrontal haemorrhage had frontal but no motor cortex signal shortening. Iron deposits do not cause cortical signal shortening in patients with ALS predominantly. Other factors are presumably more important in the generation of cortical T2 shortening in ALS.


Amyotrophic lateral sclerosis Magnetic resonance imaging T2 signal shortening T2*-weighted gradient echo Iron 


  1. 1.
    Goodin D, Rowley H, Olney R (1988) Magnetic resonance imaging in amyotrophic lateral sclerosis. Neurology 23:418–420Google Scholar
  2. 2.
    Hecht MJ, Fellner F, Fellner C, Hilz MJ, Heuss D, Neundorfer B (2001) MRI-FLAIR images of the head show corticospinal tract alterations in ALS patients more frequently than T2-, T1- and proton-density-weighted images. J Neurol Sci 186:37–44CrossRefPubMedGoogle Scholar
  3. 3.
    Hofmann E, Ochs G, Pelzl A, Warmuth-Metz M (1998) The corticospinal tract in amyotrophic lateral sclerosis. Neuroradiology 40:71–75CrossRefPubMedGoogle Scholar
  4. 4.
    Ishikawa K, Nagura H, Yokota T, Yamanouchi H (1993) Signal loss in the motor cortex on magnetic resonance images in amyotrophic lateral sclerosis. Ann Neurol 33:218–222CrossRefPubMedGoogle Scholar
  5. 5.
    Peretti-Viton P, Azulay JP, Trefouret S, Brunel H, Daniel C, Viton JM et al (1999) MRI of the intracranial corticospinal tracts in amyotrophic and primary lateral sclerosis. Neuroradiology 41:744–749CrossRefPubMedGoogle Scholar
  6. 6.
    Hecht MJ, Fellner F, Fellner C, Hilz MJ, Neundörfer B, Heuss D (2002) Hyperintense and hypointense MRI signals of the precentral gyrus and corticospinal tract in ALS: A follow-up examination including FLAIR images. J Neurol Sci 199:59–65CrossRefPubMedGoogle Scholar
  7. 7.
    Oba H, Araki T, Ohtomo K, Monzawa S, Uchiyama G, Koizumi K et al (1993) Amyotrophic lateral sclerosis: T2-shortening in motor cortex at MR imaging. Radiology 189:843–846PubMedGoogle Scholar
  8. 8.
    Imon Y, Yamaguchi S, Katayama S, Oka M, Murata Y, Kajima T et al (1998) A decrease in cerebral cortex intensity on T2-weighted with ageing images of normal subjects. Neuroradiology 40:76–80CrossRefPubMedGoogle Scholar
  9. 9.
    Waragai M (1997) MRI and clinical features in amyotrophic lateral sclerosis. Neuroradiology 39:847–851CrossRefPubMedGoogle Scholar
  10. 10.
    Ince PG (2000) Neuropathology. In: Brown RH, Meininger V, Swash M (eds) Amyotrophic lateral sclerosis. Dunitz, London, pp 83–112Google Scholar
  11. 11.
    Rockwell DT, Melhem ER, Bhatia RG (1997) GRASE (Gradient and spin-echo) MR of the brain. AJNR Am J Neuroradiol 18:1923–1928PubMedGoogle Scholar
  12. 12.
    Brooks BR, Miller RG, Swash M, Munsat TL (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1:293–299CrossRefPubMedGoogle Scholar
  13. 13.
    Hardy PA, Kucharczyk W, Henkelman RM (1990) Cause of signal loss in MR images of old hemorrhagic lesions. Radiology 174:549–555Google Scholar
  14. 14.
    Chen JC, Hardy PA, Kucharczyk W, Clauberg M, Joshi JG, Vourlas A et al (1993) MR of human postmortem brain tissue: correlative study between T2 and assys of iron and ferritin in Parkinson and Huntington disease. AJNR Am J Neuroradiol 14:275–281PubMedGoogle Scholar
  15. 15.
    Bowen BC, Pattany PM, Bradley WG, Murdoch JB, Rotta F, Younis AA et al (2000) MR imaging and localized proton spectroscopy of the precentral gyrus in myatrophic lateral sclerosis. AJNR Am J Neuroradiol 21:647–658PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. J. Hecht
    • 1
  • C. Fellner
    • 2
    • 3
  • A. Schmid
    • 2
  • B. Neundörfer
    • 1
  • F. A. Fellner
    • 2
    • 3
  1. 1.Department of NeurologyUniversity of Erlangen-NurembergErlangenGermany
  2. 2.Institute of Diagnostic RadiologyUniversity of Erlangen-NurembergErlangenGermany
  3. 3.Institute of RadiologyLandes-Nervenklinik Wagner-JaureggLinzAustria

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