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Neuroradiology

, Volume 48, Issue 5, pp 338–345 | Cite as

In vivo basal ganglia volumetry through application of NURBS models to MR images

  • Giuseppe Anastasi
  • Giuseppina Cutroneo
  • Francesco Tomasello
  • Sebastiano Lucerna
  • AntonGiulio Vitetta
  • Placido Bramanti
  • Paolo Di Bella
  • Anna Parenti
  • Andrea Porzionato
  • Veronica Macchi
  • Raffaele De CaroEmail author
Head and Neck Radiology

Abstract

Volumetry of basal ganglia (BG) based on magnetic resonance imaging (MRI) provides a sensitive marker in differential diagnosis of BG disorders. The non-uniform rational B-spline (NURBS) surfaces are mathematical representations of three-dimensional structures which have recently been applied in volumetric studies. In this study, a volumetric evaluation of BG based on NURBS was performed in 35 right-handed volunteers. We aimed to compare and validate this technique with respect to manual MRI volumetry and evaluate possible side differences between these structures. Intra- and interobserver biases less than 1.5% demonstrated the method’s stability. The mean percentage differences between NURBS and manual methods were less than 1% for all the structures considered; however, the internal segments of the globus pallidus showed a mean percentage difference of about 1.7%. Rightward asymmetry was found for the caudate nucleus (mean±SD 3.20±0.20 cm3 vs. 3.10±0.19 cm3, P<0.001) for both its head (1.44±0.10 cm3 vs. 1.41±0.09 cm3, P<0.01) and its body/tail (1.73±0.11 cm3 and 1.68±0.12 cm3, P<0.01), and for the globus pallidus (1.23±0.08 cm3 and 1.18±0.09 cm3, P<0.001) for both the internal (0.33±0.05 cm3 vs. 0.31±0.05 cm3, P<0.01) and external (0.90±0.05 cm3 vs. 0.86±0.05 cm3, P<0.001) segments. No volumetric side differences were found for the putamen (3.43±0.14 cm3 vs. 3.39±0.17 cm3, P>0.05). The rightward asymmetry of the BG may be ascribed to the predominant use of the right hand. In conclusion, NURBS is an accurate and reliable method for quantitative volumetry of nervous structures. It offers the advantage of giving a three-dimensional representation of the structures examined.

Keywords

Magnetic resonance imaging Caudate nucleus Putamen Globus pallidus 

Notes

Acknowledgement

The authors are grateful to Giuliano Carlesso for skillful technical assistance.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Giuseppe Anastasi
    • 1
  • Giuseppina Cutroneo
    • 1
  • Francesco Tomasello
    • 2
  • Sebastiano Lucerna
    • 2
  • AntonGiulio Vitetta
    • 1
  • Placido Bramanti
    • 3
  • Paolo Di Bella
    • 3
  • Anna Parenti
    • 5
  • Andrea Porzionato
    • 4
  • Veronica Macchi
    • 4
    • 5
  • Raffaele De Caro
    • 4
    Email author
  1. 1.Department of Biomorphology and BiotechnologiesUniversity of MessinaMessinaItaly
  2. 2.Department of NeurosurgeryUniversity of MessinaMessinaItaly
  3. 3.Study and Treatment Centre for Long-Stay Neurological Patients, Section of NeuroradiologyUniversity of MessinaMessinaItaly
  4. 4.Department of Human Anatomy and Physiology, Section of AnatomyUniversity of PaduaPaduaItaly
  5. 5.Department of Diagnostic Sciences and Special Therapy, Section of NeuroradiologyUniversity of PaduaPaduaItaly

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