Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: preliminary report of two cases
- First Online:
We describe two patients with symptomatic vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin daropate hydrochloride (HCl). Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated intracellular concentrations of cyclic adenosine monophosphate. We suggest that colforsin daropate HCl might be a useful therapeutic tool in treating cerebral vasospasm.
KeywordsAneurysm Colforsin daropate Subarachnoid hemorrhage Vasospasm
- 8.Himeta M, Sakashita Y, Fujita A et al (1998) Characterization of the vasodilating effects of NKH477, a novel forskolin derivative, in isolated rat aortae, canine arteries and rabbit femoral arteries and veins. Jpn Pharmacol Ther 26:775–785Google Scholar