, Volume 48, Issue 1, pp 1–7 | Cite as

Intracranial lipomas: importance of localization

  • Harun Yildiz
  • Bahattin Hakyemez
  • Mert Koroglu
  • Ahmet Yesildag
  • Bahattin Baykal
Diagnostic Neuroradiology


Intracranial lipomas are rare congenital malformations. They are usually pericallosal asymptomatic midline lesions. Other brain malformations are often seen in association with intracranial lipomas. We describe the findings of imaging studies, including computed tomography (CT), magnetic resonance (MR) imaging, and MR angiography, along with a brief review of the literature. The frequency and the spectrum of the associated brain malformations are also discussed. We retrospectively reviewed CT and MR findings of 24 patients (14 female, 10 male, mean age 38.6 years) diagnosed with intracranial lipoma between December 2000 and June 2004 in two different radiology departments. Seventeen of the patients were diagnosed using cranial MR and seven with cranial CT. The CT density of all lesions was measured. Imaging characteristics of lipomas, morphological findings and associated malformations were described. The intracranial locations of the lipomas were left-sided quadrigeminal cistern (n=3), right-sided quadrigeminal cistern (n=4), interpeduncular cistern (n=1), sylvian fissure (n=3), interhemispheric fissure (n=3), choroid plexus (n=2), intercerebellar fissure (n=3), corpus fornicis (n=1) and the periphery of the corpus callosum (n=4). Eighteen of the intracranial lipomas were tubulonodular; six were curvilinear. Associated anomalies were observed in six patients. All of the patients with sylvian fissure lipoma had seizures. The two preferential sites of intracranial lipomas were pericallosal and dorsal mesencephalic. Most intracranial lipomas are found incidentally during neuroradiological investigations. CT and MR examination usually lead to the diagnosis, because of the very low attenuation values of lipomas on CT and the short T1 and T2 on MR. Midline anomalies and other malformations such as aneurysms are frequently associated with intracranial lipomas. Careful radiologic evaluation is therefore necessary to evaluate associated pathologies. Sylvian fissure lipomas should be considered in the differential diagnosis of patients with epilepsy.


Intracranial lipoma CNS malformation Aneurysm CT MRI Epilepsy 


  1. 1.
    Friedman RB, Segal R, Latchaw RE (1986) Computerized tomographic and magnetic resonance imaging of intracranial lipoma. J Neurosurg 65:407–410PubMedGoogle Scholar
  2. 2.
    Eghwrudjakpor PPO, Kurisaka M, Fukuoka M, Mori K (1992) Intracranial lipomas: current perspectives in their diagnosis and treatment. Br J Neurosurg 6:139–144PubMedCrossRefGoogle Scholar
  3. 3.
    Truwit CL, Barkovich AJ (1990) Pathogenesis of intracranial lipoma: an MR study in 42 patients. Am J Roentgenol 155:855–865Google Scholar
  4. 4.
    Baeesa SS, Higgins MJ, Ventureyra CG (1996) Dorsal brain stem lipomas: case report. Neurosurgery 38:1031–1035PubMedCrossRefGoogle Scholar
  5. 5.
    Uchino A, Hasuo K, Matsumoto S, Masuda K (1993) MRI of dorsal mesencephalic lipomas. Clin Imaging 17:12–16PubMedCrossRefGoogle Scholar
  6. 6.
    Macpherson RI, Holgate RC, Gudeman SK (1987) Midline central nervous system lipomas in children. J Can Assoc Radiol 38:264–270Google Scholar
  7. 7.
    Donati F, Vasella F, Kaiser G, Blumberg A (1992) Intracranial lipomas. Neuropediatrics 23:32–38PubMedGoogle Scholar
  8. 8.
    Maiuri F, Cirillo S, Simonetti L, De Simone MR, Gangemi M (1988) Intracranial lipomas: diagnostic and therapeutic considerations. J Neurosurg Sci 32:161–167PubMedGoogle Scholar
  9. 9.
    Saatci I, Aslan C, Renda Y, Besim A (2000) Parietal lipoma associated with cortical dysplasia and abnormal vasculature: case report and review of the literature. Am J Neuroradiol 21:1718–1721PubMedGoogle Scholar
  10. 10.
    Catala M, Lazareth JP, Coquillo F, Binoche T (1997) Dorsal mesencephalic lipoma with inferior collicular hypoplasia: a case report and review of literature. Clin Neurol Neurosurg 99:271–275PubMedCrossRefGoogle Scholar
  11. 11.
    Barkovich AJ (2000) Congenital malformations of the brain and skull. In: Barkovich AJ (ed) Pediatric neuroimaging, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 265–266Google Scholar
  12. 12.
    Sinson G, Gennarelli TA, Wells GB (1998) Suprasellar osteolipoma: case report. Surg Neurol 50:457–460PubMedCrossRefGoogle Scholar
  13. 13.
    Friede RL (1977) Osteolipomas of the tuber cinereum. Arch Pathol Lab Med 101:369–372PubMedGoogle Scholar
  14. 14.
    List CF, Holt JF, Everett M (1946) Lipoma of the corpus callosum. Am J Roentgenol 55:125–134Google Scholar
  15. 15.
    Warakaulle DR, Anslow P (2003) Differential diagnosis of intracranial lesions with high signal on T1 or low signal on T2-weighted MRI. Clin Radiol 58:922–933PubMedCrossRefGoogle Scholar
  16. 16.
    Demaerel P, Van de Gaer P, Wilms G, Baert AL (1996) Interhemispheric lipoma with variable callosal dysgenesis: relationship between embryology, morphology, and symptomatology. Eur Radiol 6:904–909PubMedGoogle Scholar
  17. 17.
    Feldman RP, Marcovici A, Lasala PA (2001) Intracranial lipoma of the sylvian fissure: case report and review of the literature. J Neurosurg 94:515–519PubMedGoogle Scholar
  18. 18.
    Karantanas AH (2001) MR imaging of intracranial epidermoid tumors: specific diagnosis with Turbo-FLAIR pulse sequence. Comput Med Imaging Graph 25:249–255PubMedCrossRefGoogle Scholar
  19. 19.
    Chen S, Ikawa F, Kurisu K, Arita K, Takaba J, Kanou Y (2001) Quantitative MR evaluation of intracranial epidermoid tumors by fast fluid-attenuated inversion recovery imaging and echo-planar diffusion-weighted imaging. Am J Neuroradiol 22:1089–1096PubMedGoogle Scholar
  20. 20.
    Verga P (1929) Lipoma ed osteolipomi della pia madre. Tumori 15:321Google Scholar
  21. 21.
    Hadecke J, Buchfelder M, Hans-Jürgen T, Schneyer U (1997) Multiple intracranial lipoma: a case report. Neurosurg Rev 20:282–287PubMedCrossRefGoogle Scholar
  22. 22.
    Sasaki H, Yoshida K, Wakamoto H, Otani M, Toya S (1996) Lipomas of the frontal lobe. Clin Neurol Neurosurg 98:27–31PubMedCrossRefGoogle Scholar
  23. 23.
    Futami K, Kimura A, Yamashita J (1992) Intracranial lipoma associated with cerebral saccular aneurysm: case report. J Neurosurg 77:640–642PubMedCrossRefGoogle Scholar
  24. 24.
    Feldman RP, Marcovici A, Lasala PA (2001) Intracranial lipoma of the sylvian fissure: case report and review of the literature. J Neurosurg 94:515–519PubMedGoogle Scholar
  25. 25.
    Fitoz S, Atasoy C, Erden I, Akyar S (2002) Intracranial lipoma with extracranial extension through foramen ovale in a patient with encephalocraniocutaneous lipomatosis syndrome. Neuroradiology 44:175–178PubMedCrossRefGoogle Scholar
  26. 26.
    Gaskin CM, Helms CA (2004) Lipmas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. Am J Roentgenol 182:733–739Google Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Harun Yildiz
    • 1
  • Bahattin Hakyemez
    • 2
  • Mert Koroglu
    • 1
  • Ahmet Yesildag
    • 1
  • Bahattin Baykal
    • 1
  1. 1.Department of Radiology, School of MedicineSuleyman Demirel UniversityIspartaTurkey
  2. 2.BURTOMBursaTurkey

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