, Volume 46, Issue 10, pp 822–824 | Cite as

Diffusion MR findings in cyclosporin-A induced encephalopathy

  • Kubilay Aydin
  • Fuldem DonmezEmail author
  • Umit Tuzun
  • Ozenc Minareci
  • Tanju Atamer
Diagnostic Neuroradiology


Cyclosporin encephalopathy is a well-known entity, which is clinically characterized by altered mental status, vision problems, focal neurological deficits and seizures. The exact pathophysiology of the cyclosporin encephalopathy has not yet been defined. We report the diffusion-weighted MR imaging and proton MR spectroscopy findings in a case of cyclosporin encephalopathy. The white-matter lesions with reversible restricted diffusion supported the hypothesis of reversible vasospasm induced by the cyclosporin.


Cyclosporin Encephalopathy Magnetic resonance Diffusion Spectroscopy 


  1. 1.
    Gijtenbeek JMM, van den Bent MI, Vecht CJ (1999) Cyclosporin neurotoxicity: a review. J Neurol 246:339–346Google Scholar
  2. 2.
    Bartynski WS, Zeigler Z, Spearman MP, Lin L, Shadduck RK, Lister J. Lister J (2001) Etiology of cortical and white matter lesions in cyclosporin A and FK-506 neurotoxicity. Am J Neuroradiol 22:1901–1914Google Scholar
  3. 3.
    Lin J, Wang S, Fuh J, Hsiao L, Lirng J, Chen P (2003) Prolonged reversible vasospasm in cyclosporin A-induced encephalopathy. Am J Neuroradiol 24:102–104PubMedGoogle Scholar
  4. 4.
    Domingo Z, Bradley JK, Blamire AM, Brindle K, Styles P, Rajagopalan B (2000)Diffusion weighted imaging and magnetic resonance spectroscopy in a low flow ischaemia model due to endothelin induced vasospasm. NMR Biomed 13:154–162CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Kubilay Aydin
    • 1
  • Fuldem Donmez
    • 2
    • 3
    Email author
  • Umit Tuzun
    • 3
  • Ozenc Minareci
    • 1
  • Tanju Atamer
    • 4
  1. 1.Neuroradiology Division, Department of RadiologyIstanbul Medical School, Istanbul UniversityIstanbulTurkey
  2. 2.IstanbulTurkey
  3. 3.Department of Radiology, Istanbul Medical School, Istanbul UniversityIstanbulTurkey
  4. 4.Department of Internal MedicineIstanbul Medical School, Istanbul UniversityIstanbulTurkey

Personalised recommendations