, Volume 46, Issue 9, pp 781–786 | Cite as

A quantitative measure of myelination development in infants, using MR images

  • Dennis P. Carmody
  • Stanley M. Dunn
  • Akiza S. Boddie-Willis
  • J. Kevin DeMarco
  • Michael LewisEmail author
Diagnostic Neuroradiology


The objective of this study was to measure myelination of frontal lobe changes in infants and young children. Twenty-four cases of infants and children (age range 12–121 months) were evaluated by a quantitative assessment of T2-weighted MR image features. Reliable quantitative changes between white and gray matter correlated with developmental age in a group of children with no neurological findings. Myelination appears to be an increasing exponential function with the greatest rate of change occurring over the first 3 years of life. The quantitative changes observed were in accordance with previous qualitative judgments of myelination development. Children with periventricular leukomalacia (PVL) showed delays in achieving levels of myelination when compared to normal children and adjusted for chronological age. The quantitative measure of myelination development may prove to be useful in assessing the stages of development and helpful in the quantitative descriptions of white matter disorders such as PVL.


Pediatric brain White matter disease MRI Myelination 



Portions of this research were supported by USPHS grant R01-DA007109 from the National Institute on Drug Abuse to Michael Lewis


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Dennis P. Carmody
    • 1
  • Stanley M. Dunn
    • 2
  • Akiza S. Boddie-Willis
    • 2
  • J. Kevin DeMarco
    • 3
  • Michael Lewis
    • 1
    • 4
    Email author
  1. 1.Robert Wood Johnson Medical SchoolNew BrunswickUSA
  2. 2.RutgersThe State University of New JerseyNew BrunswickUSA
  3. 3.Laurie Imaging CenterNew BrunswickUSA
  4. 4.Institute for the Study of Child Development Robert Wood Johnson Medical School, University of Medicine and Dentistry of New JerseyNew BrunswickUSA

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