, Volume 46, Issue 9, pp 764–769 | Cite as

MR spectroscopy of cervical spinal cord in patients with multiple sclerosis

  • Ayşe Tuba Karagülle KendiEmail author
  • Funda Uysal Tan
  • Mustafa Kendi
  • Sinef Huvaj
  • Serdar Tellioğlu
Diagnostic Neuroradiology


MR spectroscopy (MRS) of the brain in patients with multiple sclerosis has been well studied. However, in vivo MRS of the spinal cord in patients with MR spectroscopy has not been reported to our knowledge. We performed MRS of normal-appearing cervical spinal cords in multiple sclerosis patients and in healthy controls. N-acetyl aspartate was shown to be reduced within the cervical spinal cord of multiple sclerosis patients when compared with healthy controls. This finding supports axonal loss and damage within even normal-appearing spinal cords of multiple sclerosis patients.


Multiple sclerosis Magnetic resonance spectroscopy Spinal cord 


  1. 1.
    Tartaglino LM, Friedman DP, Flanders AE, Lublin FD, Knobler RL, Liem M (1995). Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters. Radiology 195:725–732PubMedGoogle Scholar
  2. 2.
    Nusbaum AO, Fung KM, Atlas SW (2002) White matter diseases and inherited metabolic disorders. In: Atlas AS (ed) Magnetic resonance imaging of the brain and spine, 3 rd edition. Lippincott Williams & Wilkins, Philadelphia, pp 465–484Google Scholar
  3. 3.
    Sheldon JJ, Siddharthan R, Tobias J, Sheremata WA, Soila K, Viamonte M Jr (1985). MR imaging of multiple sclerosis: comparison with clinical and CT examinations in 74 patients. AJNR Am J Neuroradiol 6:683–690Google Scholar
  4. 4.
    Bot JCJ, Barkhof F, Lycklama, Nijehalt G, van Schaardenburg D, Voskuyl AE, Ader HJ, Pijnenburg JAL, Polman CH, Uitdehaag BMJ, Vermeulen EGJ, Castelijn JA (2002). Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging. Radiology 223:46–56PubMedGoogle Scholar
  5. 5.
    Honig L, Sheremata W (1989). Magnetic resonance imaging of spinal cord lesions in multiple sclerosis. J Neurol Neurosurg Psychiatry 52:459–466PubMedGoogle Scholar
  6. 6.
    Edwards MK, Farlow MR, Stevens JC (1986). Cranial MR in spinal cord MS: diagnosing patients with isolated spinal cord symptoms. AJNR Am J Neuroradiol 7:1003–1005PubMedGoogle Scholar
  7. 7.
    Bjartmar C, Kinkel RP, Kidd G, Rudick RA, Trapp BD (2001). Axonal loss in normal-appearing white matter in a patient with acute MS. Neurology 57:1248–1252PubMedGoogle Scholar
  8. 8.
    Mader I, Roser W, Kappos L, Hagberg G, Seelig J, Raude EW, Steinbrich W (2000). Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: absolute metabolic values over 2 years during a clinical pharmacological study. AJNR Am J Neuroradiol 21:1220–1227PubMedGoogle Scholar
  9. 9.
    Lee MA, Blamire AM, Pendlebury S et al (2000). Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis. Arch Neurol 57:65–70CrossRefPubMedGoogle Scholar
  10. 10.
    Gomez-Anson B, MacManus DG, Parker GJM, Davie CA, Barker GJ, Moseley IF, McDonald WI, Miller DH (2000). In vivo H-magnetic resonance spectroscopy of the spinal cord in humans. Neuroradiology 42:515–517CrossRefPubMedGoogle Scholar
  11. 11.
    Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997). Axonal damage in acute multiple sclerosis lesions. Brain 120:393–399CrossRefPubMedGoogle Scholar
  12. 12.
    Bjartmar C, Kidd G, Mörk S, Rudick R, Trapp BD (2000). Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann Neurol 48:893–902CrossRefPubMedGoogle Scholar
  13. 13.
    Arnold DL, Reiss GT, Matthews PM et al (1994). Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Ann Neurol 36:76–82PubMedGoogle Scholar
  14. 14.
    De Stefano N, Matthews PM, Fu L et al (1998). Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy. Brain 121:1469–1477CrossRefPubMedGoogle Scholar
  15. 15.
    Vink R, Noble LJ, Knoblach SM, Bendall MR, Faden AI (1989). Metabolic changes in rabbit spinal cord after trauma: magnetic resonance spectroscopy studies. Ann Neurol 25:26–31PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Ayşe Tuba Karagülle Kendi
    • 1
    • 5
    Email author
  • Funda Uysal Tan
    • 2
  • Mustafa Kendi
    • 3
  • Sinef Huvaj
    • 4
  • Serdar Tellioğlu
    • 2
  1. 1.Center for MR ResearchUniversity of MinnesotaMinneapolisUSA
  2. 2.Neurology DepartmentKırıkkale University School of MedicineKırıkkaleTurkey
  3. 3.MinneapolisUSA
  4. 4.Radiology DepartmentKırıkkale University School of MedicineKırıkkaleTurkey
  5. 5.Radiology DepartmentKırıkkale University School of MedicineKırıkkaleTurkey

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