, Volume 45, Issue 10, pp 708–712 | Cite as

Corticobasal degeneration: structural and functional MRI and single-photon emission computed tomography

  • M. Ukmar
  • R. Moretti
  • P. Torre
  • R. M. Antonello
  • R. Longo
  • A. Bava
Diagnostic Neuroradiology


We studied seven patients with corticobasal degeneration (CBD) from a clinical and imaging perspective. We describe the main morphological features of CBD and, using functional MRI, try to define the possible role of the parietal lobe in simple and complex learned motor sequences. We showed decreased activation of the parietal lobe contralateral to the more affected arm, when movements, simple or complex, are performed with that hand. Moreover we found that functional imaging can demonstrate parietal and motor cortex dysfunction before structural, and even single-photon emission computed tomography changes become evident.


Corticobasal degeneration Parietal lobe Functional magnetic resonance imaging Single-photon emission computed tomography 



This study was supported by grants from the Ministero dell'Università e della Ricerca Scientifica e tecnologica, Roma, from the Università degli Studi di Trieste and from the Consorzio per lo Sviluppo Internazionale dell'Università degli Studi di Trieste and by Fondazione C. e D. Callerio, Laboratori di Ricerche Biologiche, Trieste, Italia.


  1. 1.
    Riley D, Lang A, Lewis A., et al (1990) Cortical-basal ganglionic degeneration. Neurology 40: 1203–1212PubMedGoogle Scholar
  2. 2.
    Rinne J, Lee M, Thompson P, Marsden C (1994) Corticobasal degeneration: a clinical study of 36 cases. Brain 117: 1183–1196PubMedGoogle Scholar
  3. 3.
    Lang A (1994) Cortico-basal ganglionic degeneration. In: Calne DB (ed) Neurodegenerative diseases. Saunders, Philadelphia, pp 877–894Google Scholar
  4. 4.
    Grimes DA, Lang AE, Bergeron C (1998) Dementia is the most common presentation of cortical-basal ganglionic degeneration. Neurology 50 [Suppl 4]: A96Google Scholar
  5. 5.
    Revesz T, Geddes JF, Daniel SE (1995) Corticobasal degeneration. In: Cruz-Sánchez FF, Ravid R, Cuzner ML (eds) Neuropathological diagnostic criteria for brain banking. Amsterdam Press, Amsterdam pp 99–104Google Scholar
  6. 6.
    Litvan I, Agid Y, Goetz C (1997) Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathologic study. Neurology 48: 119–125PubMedGoogle Scholar
  7. 7.
    Gibb WRC, Luthert PJ, Marsden CD(1990) Clinical and pathological features of corticobasal degeneration. Adv Neurol 53: 51–54PubMedGoogle Scholar
  8. 8.
    Feary MB, Dickson DW (1995) Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 146: 1338–1396Google Scholar
  9. 9.
    Schneider JA, Watts RL, Gearing M, Mirra SS (1997) Corticobasal degeneration: neuropathologic and clinical heterogeneity. Neurology 48: 959–969PubMedGoogle Scholar
  10. 10.
    Leiguarda R, Lees A, Morello M, Marsden C(1994) The nature of apraxia in corticobasal degeneration. J Neurol Neurosurg Psychiatry 57: 455–459PubMedGoogle Scholar
  11. 11.
    Briggs GC, Nebes R.D (1975) Patterns of hand preference in a student population. Cortex 11: 230–238PubMedGoogle Scholar
  12. 12.
    Raven JC (1938) Standard progressive matrices. H.K. Lewis, LondonGoogle Scholar
  13. 13.
    Spinnler H, Tognoni G (1987) Standardizzazione e taratura italiana dei test neuropsicologici. Ital J Neurol Sci [Suppl 6]: 23–116Google Scholar
  14. 14.
    Wechsler D (1995) Wechsler adult intelligence scale manual. Grune & Stratton, New YorkGoogle Scholar
  15. 15.
    Poeck K (1994) Neurologie. Springer-Verlag, Berlin, pp 58–73Google Scholar
  16. 16.
    Wechsler D (1945) A standardized memory scale for clinical use. J Psychol 19: 87–97Google Scholar
  17. 17.
    Benton L, Hamsher K, Varney N, Spreen O (1983) Contributions to neuropsychological assessment. Oxford University Press, New YorkGoogle Scholar
  18. 18.
    Manos PJ, Wu R (1994) The ten point test: a quick screen and grading method for cognitive impairment in medical and surgical patients. Int J Psych Med 24: 229–244Google Scholar
  19. 19.
    Sobol WT, Gaunt DM (1996) On the stationary states in gradient echo imaging. J Magn Reson Imag 6: 384–398Google Scholar
  20. 20.
    Salvador S, Brovelli A, Longo R (2002) A simple and fast technique for on-line f-MRI data analysis. Magn Reson Imaging 20: 207–213CrossRefPubMedGoogle Scholar
  21. 21.
    Ballan G, Tison F, Dousset V, Vidailhet M, Agid Y, Henry P (1998) Study of cortical atrophy with magnetic resonance imaging in corticobasal degeneration. Rev Neurol 154: 224–227PubMedGoogle Scholar
  22. 22.
    Markus HS, Lees AJ, Lennox G, Marsden CD, Costa DC (1995) Patterns of regional cerebral blood flow in corticobasal degeneration studied using HMPAO-SPECT; comparison with Parkinson's disease and normal controls. Mov Disord 10: 179–187PubMedGoogle Scholar
  23. 23.
    Roland PE (1997) Brain activation: motor functions. Wiley-Liss, New York, pp 105–108Google Scholar
  24. 24.
    Rizzolatti G, Luppino G, Matelli M (1996) The classic supplementary motor area is formed by two independent areas. In: Lunders HO (ed): Supplementary sensorimotor area. Lippincott Raven, Philadelphia, pp 45–56Google Scholar
  25. 25.
    Wiesendanger M, Kazennikov O, Perrig S, Roviller E, Kermadi I (1997) Reaching, grasping and bimanual coordination with special reference to the posterior parietal cortex. In: Thier P, Karnath HO (eds) Parietal lobe contributions to orientation in 3D space. Springer-Verlag, Berlin, pp 271–288Google Scholar
  26. 26.
    Mountcastle VB (1995) The parietal system and some higher brain functions. Cereb Cortex 5: 377–390PubMedGoogle Scholar
  27. 27.
    Glickstein M (2000) How are visual areas of the brain connected to motor areas for the sensory guidance of movement? Trends Neurosci 23: 613–617PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • M. Ukmar
    • 1
  • R. Moretti
    • 2
  • P. Torre
    • 3
  • R. M. Antonello
    • 3
  • R. Longo
    • 4
  • A. Bava
    • 2
  1. 1.Department of RadiologyOspedale di Cattinara, University of TriesteTriesteItaly
  2. 2.Department of Physiology and PathologyOspedale di Cattinara, University of TriesteTriesteItaly
  3. 3.Department of Internal Medicine and Clinical NeurologyOspedale di Cattinara, University of TriesteTriesteItaly
  4. 4.Department of PhysicsUniversity of TriesteTriesteItaly

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