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Neuroradiology

, Volume 45, Issue 1, pp 34–38 | Cite as

Diffuse axonal injury: detection of changes in anisotropy of water diffusion by diffusion-weighted imaging

  •  J. Chan
  •  E. Tsui
  •  W. Peh
  •  D. Fong
  •  K. Fok
  •  K. Leung
  •  M. Yuen
  •  K. Fung
Diagnostic Neuroradiology

Abstract.

Myelinated axons of white matter demonstrate prominent directional differences in water diffusion. We performed diffusion-weighted imaging on ten patients with head injury to explore the feasibility of using water diffusion anisotropy for quantitating diffuse axonal injury. We showed significant decrease in diffusion anisotropy indices in areas with or without signal abnormality on T2 and T2*-weighted images. We conclude that the water diffusion anisotropy index a potentially useful, sensitive and quantitative way of diagnosing and assessing patients with diffuse axonal injury.

Head injury Diffuse axonal injury Diffusion-weighted imaging 

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  •  J. Chan
    • 1
  •  E. Tsui
    • 1
  •  W. Peh
    • 2
  •  D. Fong
    • 3
  •  K. Fok
    • 3
  •  K. Leung
    • 3
  •  M. Yuen
    • 1
  •  K. Fung
    • 4
  1. 1.Department of Diagnostic Radiology, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, N.T., Hong Kong, China
  2. 2.Department of Diagnostic Radiology, Singapore General Hospital, Singapore
  3. 3.Department of Neurosurgery, Tuen Mun Hospital, Hong Kong
  4. 4.Department of Optometry and Radiography, Hong Kong Polytechnic University, Hong Kong

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