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Bidirectional Regulatory Mechanisms of Jaceosidin on Mitochondria Function: Protective Effects of the Permeability Transition and Damage of Membrane Functions

  • Wen-Rong Fu
  • Ji-Lei Chen
  • Xue-Yi Li
  • Jia-Xin DongEmail author
  • Yi LiuEmail author
Article
  • 15 Downloads

Abstract

Many natural products could induce apoptosis through mitochondrial pathways. However, direct interactions between natural products and mitochondria have rarely been reported. In this work, the effects and regulatory mechanisms of Jaceosidin on the isolated rat liver mitochondria have been studied. The results of the experiments which by introducing exogenous Ca2+ illustrated that Jaceosidin has the protective effects on the structure and function of the isolated mitochondria. These protective effects were related to the chelation of Ca2+ with Jaceosidin. Besides, Jaceosidin could scavenge reactive oxygen species produced during electron transport, and weaken the mitochondrial lipid peroxidation rate, which may be attributed to the antioxidant effect of phenolic hydroxyl groups of Jaceosidin. In addition, Jaceosidin has some damage effects on mitochondrial function, such as the inhibition of mitochondrial respiration and the increase of mitochondrial membrane fluidity. These results of this work provided comprehensive information to clarify the mechanisms of Jaceosidin on mitochondria, which may be the bidirectional regulatory mechanisms.

Keywords

Jaceosidin Bidirectional regulatory Protective effect Mitochondrial permeability transition Membrane function damage 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 21463008) and Bagui Scholar Program of Guangxi Province (2016).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

The Wistar rats used in this work were handled according to the Guidelines of the China Animal Welfare Legislation, as approved by the Committee on Ethics in the Care and Use of Laboratory Animals of the College of Life Sciences, Wuhan University.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilinPeople’s Republic of China
  2. 2.State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry and Molecular SciencesWuhan UniversityWuhanPeople’s Republic of China
  3. 3.Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, College of Chemistry and Chemical EngineeringWuhan University of Science and TechnologyWuhanPeople’s Republic of China
  4. 4.Guangxi Key Laboratory of Natural Polymer Chemistry, College of Chemistry and Material SciencesNanning Normal UniversityNanningPeople’s Republic of China

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