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The Journal of Membrane Biology

, Volume 252, Issue 6, pp 617–626 | Cite as

Transport of Docosahexaenoic Acid via the Human Placenta: A Theoretical Study

  • Efrath BartaEmail author
Article
  • 57 Downloads

Abstract

The high demand of the fetus for Docosahexaenoic acid, DHA, is satisfied by a concert of several mechanisms that take place in the placental terminal villi. Scarcity of laboratory data makes the detailed description of these mechanisms elusive. Here, the DHA transport across the placenta is modeled as a boundary value problem that accounts for diffusion, reactions with fatty acids binding proteins, FABPs, and metabolic consumption within the Syncytiotrophoblast, ST. For any given DHA fluxes at the bordering membranes, analytical and numerical solutions yield the DHA concentration profile within the ST. We find that in order to comply with adequate DHA delivery to the fetus and with physiological DHA concentrations in the maternal and fetal circulations, it is essential to have a significant rise of DHA concentration at the microvillus membrane, MVM and a rapid dissociation of the DHA from the FABP. The model establishes the relations between the concentrations of the FABPs in the ST, their equilibrium dissociation constant from the DHA, and the placental DHA metabolic degradation rate, hitherto unknown. We conclude that the bound (to the protein) DHA molecule is degraded at a rate of 0.3–0.45 s−1.

Keywords

DHA uptake Mathematical modeling Placenta 

Notes

Compliance with Ethical Standards

Conflict of interest

The author declares that she has no conflict of interest.

Research Involving Human and Animal Rights

This article does not contain any studies with human participants or animals performed by the author.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Bar-Code Computers Ltd.Tirat-CarmelIsrael

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