The Journal of Membrane Biology

, Volume 252, Issue 4–5, pp 413–423 | Cite as

Rhodopsin Oligomerization and Aggregation

  • Paul S.-H. ParkEmail author
Part of the following topical collections:
  1. Membrane and Receptor Dynamics


Rhodopsin is the light receptor in photoreceptor cells of the retina and a prototypical G protein-coupled receptor. Two types of quaternary structures can be adopted by rhodopsin. If rhodopsin folds and attains a proper tertiary structure, it can then form oligomers and nanodomains within the photoreceptor cell membrane. In contrast, if rhodopsin misfolds, it cannot progress through the biosynthetic pathway and instead will form aggregates that can cause retinal degenerative disease. In this review, emerging views are highlighted on the supramolecular organization of rhodopsin within the membrane of photoreceptor cells and the aggregation of rhodopsin that can lead to retinal degeneration.


G protein-coupled receptor Quaternary structure Photoreceptor cell Retina Phototransduction Retinal degeneration 



This work was funded by a Grant from the National Institutes of Health (R01EY021731).

Compliance with Ethical Standards

Conflict of interest

The author declares that he has no conflicts of interest to disclose.

Ethical Approval

This article does not contain any studies with human participants or animals performed by the author.


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Authors and Affiliations

  1. 1.Department of Ophthalmology and Visual SciencesCase Western Reserve UniversityClevelandUSA

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