The Journal of Membrane Biology

, Volume 248, Issue 4, pp 611–640 | Cite as

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

  • Zoe Cournia
  • Toby W. Allen
  • Ioan Andricioaei
  • Bruno Antonny
  • Daniel Baum
  • Grace Brannigan
  • Nicolae-Viorel Buchete
  • Jason T. Deckman
  • Lucie Delemotte
  • Coral del Val
  • Ran Friedman
  • Paraskevi Gkeka
  • Hans-Christian Hege
  • Jérôme Hénin
  • Marina A. Kasimova
  • Antonios Kolocouris
  • Michael L. Klein
  • Syma Khalid
  • M. Joanne Lemieux
  • Norbert Lindow
  • Mahua Roy
  • Jana Selent
  • Mounir Tarek
  • Florentina Tofoleanu
  • Stefano Vanni
  • Sinisa Urban
  • David J. Wales
  • Jeremy C. Smith
  • Ana-Nicoleta Bondar
Topical Review

Abstract

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

Keywords

Membrane proteins Lipids Protein structure Protein function Protein dynamics Membrane-mediated interactions 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Zoe Cournia
    • 1
  • Toby W. Allen
    • 2
    • 3
  • Ioan Andricioaei
    • 4
  • Bruno Antonny
    • 5
  • Daniel Baum
    • 6
  • Grace Brannigan
    • 7
  • Nicolae-Viorel Buchete
    • 8
  • Jason T. Deckman
    • 4
  • Lucie Delemotte
    • 9
  • Coral del Val
    • 10
  • Ran Friedman
    • 11
  • Paraskevi Gkeka
    • 1
  • Hans-Christian Hege
    • 6
  • Jérôme Hénin
    • 12
  • Marina A. Kasimova
    • 13
    • 14
  • Antonios Kolocouris
    • 15
  • Michael L. Klein
    • 9
  • Syma Khalid
    • 16
  • M. Joanne Lemieux
    • 17
  • Norbert Lindow
    • 6
  • Mahua Roy
    • 4
  • Jana Selent
    • 18
  • Mounir Tarek
    • 13
    • 19
  • Florentina Tofoleanu
    • 8
  • Stefano Vanni
    • 5
  • Sinisa Urban
    • 20
  • David J. Wales
    • 21
  • Jeremy C. Smith
    • 22
  • Ana-Nicoleta Bondar
    • 23
  1. 1.Biomedical Research FoundationAcademy of AthensAthensGreece
  2. 2.Department of ChemistryUniversity of California, DavisDavisUSA
  3. 3.School of Applied Sciences and Health Innovations Research InstituteRMIT UniversityMelbourneAustralia
  4. 4.Department of ChemistryUniversity of CaliforniaIrvineUSA
  5. 5.Institut de Pharmacologie Moléculaire et CellulaireUniversité de Nice Sophia-Antipolis and Centre National de la Recherche ScientifiqueNiceFrance
  6. 6.Department of Visual Data AnalysisZuse Institute BerlinBerlinGermany
  7. 7.Department of Physics, Center for Computational and Integrative BiologyRutgers University-CamdenCamdenUSA
  8. 8.School of Physics and Complex and Adaptive Systems LaboratoryUniversity College DublinDublin 4Ireland
  9. 9.Institute of Computational and Molecular ScienceTemple UniversityPhiladelphiaUSA
  10. 10.Department of Artificial IntelligenceUniversity of GranadaGranadaSpain
  11. 11.Department of Chemistry and Biomedical Sciences and Centre for Biomaterials ChemistryLinnæus UniversityKalmarSweden
  12. 12.Laboratoire de Biochimie ThéoriqueIBPC and CNRSParisFrance
  13. 13.Université de Lorraine, SRSMCVandoeuvre-Lès-NancyFrance
  14. 14.Lomonosov Moscow State UniversityMoscowRussian Federation
  15. 15.Department of Pharmaceutical Chemistry, Faculty of PharmacyUniversity of AthensAthensGreece
  16. 16.Department of ChemistryUniversity of SouthamptonSouthamptonUK
  17. 17.Department of Biochemistry, Faculty of Medicine and Dentistry, Membrane Protein Disease Research GroupUniversity of AlbertaEdmontonCanada
  18. 18.Department of Experimental and Health Sciences, Research Programme on Biomedical Informatics (GRIB)Universitat Pompeu Fabra, IMIM (Hospital del Mar Medical Research Institute)BarcelonaSpain
  19. 19.CNRS, SRSMCVandoeuvre-Lès-NancyFrance
  20. 20.Department of Molecular Biology and Genetics, Howard Hughes Medical InstituteJohns Hopkins University School of MedicineBaltimoreUSA
  21. 21.University Chemical LaboratoriesUniversity of CambridgeCambridgeUK
  22. 22.Oak Ridge National LaboratoryOak RidgeUSA
  23. 23.Theoretical Molecular Biophysics, Department of PhysicsFreie Universität BerlinBerlinGermany

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