Phloretin-Induced Reduction in Dipole Potential of Sterol-Containing Bilayers
- 166 Downloads
The phloretin-induced reduction in the dipole potential of planar lipid bilayers containing cholesterol, ergosterol, stigmasterol, 7-dehydrocholesterol and 5α-androstan-3β-ol was investigated. It is shown that effects depend on the type and concentration of membrane sterol. It is supposed that the effectiveness of phloretin in reducing the dipole potential of the bilayers that contain cholesterol, ergosterol and 7-dehydrocholesterol correlates with the ordering and condensing effects. The role of the concentration-dependent ability of different sterols to promote lateral heterogeneity in membranes is also discussed.
KeywordsPhloretin Membrane dipole potential Sterol Lipid bilayer
We are grateful to Prof. Valery V. Malev for fruitful discussions. This work was partly supported by the Russian Foundation for Basic Research (Grants 12-04-00948, 12-04-31332, 12-04-33121), the Program “Molecular and Cell Biology” of the Russian Academy of Sciences, a Grant from the president of RF (MK-1813.2012.4) and Russian state contract 8119 (MES, FTP, SSEPIR).
- Disalvo EA, Lairion F, Martini F, Almaleck H (2004) Water in biological membranes at interfaces: does it play a functional role? J Argent Chem Soc 92:1–22Google Scholar
- Sackmann E (1995) Biological membranes architecture and function. In: Lipowsky R, Sackmann E (eds) Structure and dynamics of membranes. Elsevier, Amsterdam, pp 1–64Google Scholar
- Tsybulskaya MV, Antonenko YN, Tropsch AE, Yaguzhinskii LS (1984) Iodine-containing hormones—dipole modifiers of phospholipid membranes [in Russian]. Biophysics 29:801–805Google Scholar
- Xu X, Bittman R, Duportail G, Heissler D, Vilcheze C, London E (2001) Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide. J Biol Chem 276:33540–33546CrossRefPubMedGoogle Scholar