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The Journal of Membrane Biology

, Volume 246, Issue 1, pp 47–55 | Cite as

Therapeutic Potential of Some Plant Extracts Used in Turkish Traditional Medicine on Streptozocin-Induced Type 1 Diabetes Mellitus in Rats

  • Halil Ozkol
  • Yasin Tuluce
  • Nihat Dilsiz
  • İsmail Koyuncu
Article

Abstract

Diabetes mellitus (DM) is known to impair many physiological functions. Some reports claim that medicinal plants can reduce these alterations caused by DM. The aim of this study was to investigate the therapeutic potential of aqueous-methanol extracts of Urtica dioica, Thymus vulgaris (TV), Myrtus communis (MC), Scolymus hispanicus (SH) and Cinnamomun zeylanicum (CZ) on streptozotocin (STZ)-induced type 1 DM in rats. Diabetes was induced via a single i.p. injection of STZ (65 mg/kg body weight). After 1 week to allow for development of diabetes, each plant extract was administered to diabetic rats separately at a dose of 100 mg/kg body weight daily for 28 days. The results showed that only SH extract significantly (P < 0.05) amended fasting blood glucose level. The lipid profile was ameliorated especially by supplementations of TV, MC and CZ extracts. Almost all plant extract treatments markedly (P < 0.05) increased reduced glutathione content and decreased lipid peroxidation levels of erythrocyte, plasma, retina and lens tissues. They also significantly (P < 0.05) amended erythrocyte catalase activity, levels of marker serum enzymes (except amylase), urea and blood urea nitrogen when compared to diabetic rats treated with nothing. Furthermore, none of the plant extracts counteracted body weight loss of diabetic rats. Our data revealed that the aforementioned plant extracts have remarkable potential to counteract DM-caused alterations, probably through their antioxidant and free radical-defusing effects.

Keywords

Diabetes mellitus Plant extract Retina Lens Antioxidant Free radical 

Notes

Acknowledgments

We thank Prof. Dr. İsmail Meral for reviewing the manuscript.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Halil Ozkol
    • 1
  • Yasin Tuluce
    • 1
  • Nihat Dilsiz
    • 2
  • İsmail Koyuncu
    • 2
  1. 1.Department of Medical Biology, Faculty of MedicineYuzuncu Yil UniversityVanTurkey
  2. 2.Department of Biology, Faculty of Science & ArtHarran UniversityS. UrfaTurkey

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