The Journal of Membrane Biology

, Volume 245, Issue 12, pp 763–777 | Cite as

Breast Cancer Proteome Takes More Than Two to Tango on TRAIL: Beat Them at Their Own Game

  • Ammad Ahmad Farooqi
  • Sundas Fayyaz
  • Muhammad Tahir
  • Muhammed Javed Iqbal
  • Shahzad Bhatti
Topical Review


Breast carcinogenesis is a multidimensional disease that has resisted drug-related solutions to date because of heterogeneity, disorganized spatiotemporal behavior of signal transduction cascades, cell cycle checkpoints, cell transition, plasticity, and impaired pro-apoptotic response. These synchronized oncogenic events, including protein–protein interaction, transcriptional–regulatory, and signaling networks, trigger genomic and transcriptional disturbances in TRAIL-mediated signaling network neighborhoods. Therefore, tumor cells often acquire the ability to escape death by suppressing cell death pathways that normally function to eliminate damaged and harmful cells. This review describes the TRAIL-mediated cell death signaling pathways, the interactions between these pathways, and the ways in which these pathways are deregulated in breast cancer.


Biochemistry/molecular biology Cell physiology Cell signaling Membrane transport Membrane-drug physical interaction Structure function membrane rafts Transport physiology 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Ammad Ahmad Farooqi
    • 1
  • Sundas Fayyaz
    • 1
    • 2
  • Muhammad Tahir
    • 3
  • Muhammed Javed Iqbal
    • 2
  • Shahzad Bhatti
    • 2
  1. 1.Lab for Translational Oncology and Personalized MedicineRashid Latif Medical College (RLMC)LahorePakistan
  2. 2.IMBBThe University of LahoreLahorePakistan
  3. 3.Department of SurgeryUniversity College of MedicineLahorePakistan

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