The Journal of Membrane Biology

, Volume 236, Issue 1, pp 43–53 | Cite as

Interaction Between Equally Charged Membrane Surfaces Mediated by Positively and Negatively Charged Macro-Ions

  • Šárka Perutková
  • Mojca Frank
  • Klemen Bohinc
  • Goran Bobojevič
  • Jasna Zelko
  • Blaž Rozman
  • Veronika Kralj-Iglič
  • Aleš Iglič
Article

Abstract

In biological systems, charged membrane surfaces are surrounded by charged molecules such as electrolyte ions and proteins. Our recent experiments in the systems of giant phospholipid vesicles indicated that some of the blood plasma proteins (macro-ions) may promote adhesion between equally charged membrane surfaces. In this work, theory was put forward to describe an IgG antibody-mediated attractive interaction between negatively charged membrane surfaces which was observed in experiments on giant phospholipid vesicles with cardiolipin-containing membranes. The attractive interactions between negatively charged membrane surfaces in the presence of negatively and positively charged spherical macro-ions are explained using functional density theory and Monte Carlo simulations. Both, the rigorous solution of the variational problem within the functional density theory and the Monte Carlo simulations show that spatial and orientational ordering of macro-ions may give rise to an attractive interaction between negatively charged membrane surfaces. It is also shown that the distinctive spatial distribution of the charge within the macro-ions (proteins) is essential in this process.

Keywords

Macro-ion Electric double layer Functional density theory Monte Carlo simulation Adhesion 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Šárka Perutková
    • 1
  • Mojca Frank
    • 2
  • Klemen Bohinc
    • 1
    • 3
  • Goran Bobojevič
    • 4
    • 5
  • Jasna Zelko
    • 5
  • Blaž Rozman
    • 2
  • Veronika Kralj-Iglič
    • 5
  • Aleš Iglič
    • 1
  1. 1.Laboratory of Biophysics, Faculty of Electrical EngineeringUniversity of LjubljanaLjubljanaSlovenia
  2. 2.Department of RheumatologyUniversity Medical Center LjubljanaLjubljanaSlovenia
  3. 3.Faculty of Health StudiesUniversity of LjubljanaLjubljanaSlovenia
  4. 4.Laboratory of Telecommunications, Faculty of Electrical EngineeringUniversity of LjubljanaLjubljanaSlovenia
  5. 5.Laboratory of Clinical Biophysics, Faculty of MedicineUniversity of LjubljanaLjubljanaSlovenia

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