The Journal of Membrane Biology

, Volume 199, Issue 2, pp 113–118 | Cite as

Optimal-Sensitivity Analysis of Ion Channel Gating Kinetics



We propose a new approach to analysis of kinetic models for ion channel gating, based on application of fluctuating voltages through a voltage clamp, in addition to conventional techniques. We show that the channel kinetics can be probed in a much more sensitive way, leading to more efficient model selection and more reliable estimates of model parameters. We use wavelet transform as an analytic tool for fluctuating currents and parametric dispersion plots as a measure of model compatibility with experimental data.


Voltage-gated ion channels Markov models Nonequilibrium response spectroscopy Wavelets 


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Physics DepartmentLoyola University New OrleansNew OrleansUSA
  2. 2.Department of Physiology and BiophysicsUniversity of Arkansas for Medical SciencesLittle RockUSA

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