European Journal of Clinical Pharmacology

, Volume 57, Issue 6–7, pp 505–508 | Cite as

Concomitant prescription of non-steroidal anti-inflammatory drugs and antacids in the outpatient setting of a medical center in Taiwan: a prescription database study

  • Jui-Yao Liu
  • Tzeng-Ji Chen
  • Shinn-Jang Hwang
Pharmacoepidemiology and Prescription

Abstract.

Objective: Although antacids were ineffective in preventing serious gastrointestinal complications caused by non-steroidal anti-inflammatory drugs (NSAIDs), many physicians in Taiwan still prescribe antacids concomitantly with NSAIDs. A survey of an outpatient prescription database was performed to measure the extent of such a combination and to explore its associated factors. Methods: One month of the outpatient prescription data in the polyclinic of a medical center in Taiwan served to estimate the frequency of concomitant antacid prescription with NSAIDs. The age of patients, duration of NSAID prescriptions, concomitant prescription of corticosteroid or ulcer-healing drugs, and inter-departmental variations were compared between the NSAID prescriptions with and without antacids. Results: Antacids were present in 87.3% of prescriptions with NSAIDs but only in 34.4% of prescriptions without NSAIDs (P<0.001). The prescription of antacids was significantly associated with the prescription of NSAIDs. The age of patients and duration of NSAID prescriptions did not influence the co-prescription of NSAIDs and antacids. Significant inter-departmental variations were noted in which the surgeons and orthopedic doctors tended to co-prescribe antacids with NSAIDs more often than the internists. Conclusion: The physicians in Taiwan tended to prescribe NSAIDs together with antacids. The rationality of this co-prescription deserves further investigation.

Antacid Concomitant prescription Non-steroidal anti-inflammatory drug 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Jui-Yao Liu
    • 1
  • Tzeng-Ji Chen
    • 1
  • Shinn-Jang Hwang
    • 1
  1. 1.Department of Family Medicine, Taipei Veterans General Hospital, 112 Taipei, Taiwan

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