European Journal of Clinical Pharmacology

, Volume 57, Issue 1, pp 11–17

Genetic polymorphism of CYP2D6 and CYP2C19 in East- and Southern African populations including psychiatric patients

  • Collet Dandara
  • Collen Mutowembwa Masimirembwa
  • Ayoub Magimba
  • Jane Sayi
  • Sylvia Kaaya
  • De K. Sommers
  • J.R. Snyman
  • Julia Anne Hasler
Pharmacokinetics and Disposition

DOI: 10.1007/s002280100282

Cite this article as:
Dandara, C., Mutowembwa Masimirembwa, C., Magimba, A. et al. Eur J Clin Pharmacol (2001) 57: 11. doi:10.1007/s002280100282

Abstract.

Objectives: The study was carried out to investigate the distribution of cytochrome P450 2D6 (CYP2D6) and CYP2C19 genotype frequencies in three African populations and to compare these frequencies between healthy individuals and psychiatric patients. Methods: Three hundred and eighty-four subjects from South Africa (Venda), Tanzania, and Zimbabwe who consented to the study were genotyped for CYP2D6 (CYP2D6*1, *2, *3, *4, *5, and *17) and CYP2C19 (CYP2C19*1, *2, and *3) by PCR-RFLP (polymerase chain reaction restriction fragment length polymorphism) techniques. Results: The genotypes for CYP2D6 predicted a poor metaboliser frequency of 2.3% (2/88) in Tanzanian psychiatric patients, 1.9% (2/106) in Tanzanian healthy controls and 2.6% (2/76) in the South African Venda. The low-activity CYP2D6*17 allele frequency was higher in psychiatric patients (30%, 53/176) than in healthy individuals (20%, 43/212) in Tanzanians. The frequencies for CYP2C19*2 genotypes were predictive of a low prevalence of poor metabolisers (PMs). The CYP2C19*3 allele was absent in the three populations studied. There was no difference in CYP2D6 or CYP2C19 PM genotype frequencies between psychiatric patients and healthy subjects. Conclusion: The genotype results predict a low prevalence of people with deficient CYP2D6 and CYP2C19 activity among linguistically (Bantu) related populations of East and Southern Africa. The high frequency of the low-activity CYP2D6*17 allele predicts that the Bantu people have a reduced capacity to metabolise drugs that are CYP2D6 substrates.

African populations Genetic polymorphism 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Collet Dandara
    • 1
  • Collen Mutowembwa Masimirembwa
    • 1
  • Ayoub Magimba
    • 2
  • Jane Sayi
    • 2
  • Sylvia Kaaya
    • 2
  • De K. Sommers
    • 3
  • J.R. Snyman
    • 3
  • Julia Anne Hasler
    • 4
  1. 1.Department of Biochemistry, University of Zimbabwe, HarareZimbabwe
  2. 2.Muhimbili University College of Health Sciences, Dar-Es-SalaamTanzania
  3. 3.Department of Pharmacology, University of PretoriaSouth Africa
  4. 4.Department of Biochemistry, University of Zimbabwe, P.O. Box MP 167, Mount Pleasant, HarareZimbabwe

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