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European Journal of Clinical Pharmacology

, Volume 54, Issue 6, pp 455–458 | Cite as

Comparison of ketorolac and diclofenac in the treatment of renal colic

  • E. Cohen
  • R. Hafner
  • Z. Rotenberg
  • M. Fadilla
  • M. Garty
PHARMACODYNAMICS

Abstract

Objective: To compare the efficacy and adverse effects of ketorolac and diclofenac in the treatment of renal colic.

Methods: In a double-blind, randomized clinical trial, 57 patients admitted to the emergency room for renal colic, received either 30 mg of ketorolac or 75 mg of diclofenac i.m. (intramuscularly). Evaluations were performed at 1, 2 h and 6 h after treatment. Pain was assessed by a four-point verbal rating scale (VRS) and a visual analogue scale (VAS). Only patients with at least moderate pain according to the VRS were included. Seventy-five milligrams of pethidine i.m. was given as rescue medicine, if insufficient analgesia was achieved. The adverse effects recorded were sedation, nausea and vomiting.

Results: There was no significant difference between ketorolac and diclofenac, with respect to pain level over time, the number of patients requiring rescue medicine, or the level of adverse effects.

Conclusion: Ketorolac and diclofenac are equally effective in the treatment of renal colic.

Key words Ketorolac Diclofenac Renal colic 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • E. Cohen
    • 1
  • R. Hafner
    • 1
  • Z. Rotenberg
    • 2
  • M. Fadilla
    • 2
  • M. Garty
    • 1
  1. 1.Internal Medicine F Department & The Clinical Pharmacology Unit, Rabin Medical Center, Beilinson Campus, Petach-Tikva, Israel Fax: +972-3-9244663IL
  2. 2.Emergency Department, Rabin Medical Center, Petach-Tikva, IsraelIL

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