European Journal of Clinical Pharmacology

, Volume 54, Issue 2, pp 141–147

The extrapulmonary effects of increasing doses of formoterol in patients with asthma

  • C. D. Burgess
  • M. Ayson
  • S. Rajasingham
  • J. Crane
  • G. Della Cioppa
  • M. D. Till
PHARMACODYNAMICS

Abstract

Objective: To assess the cardiovascular and metabolic responses to increasing doses of formoterol administered from a dry powder inhaler. Methods: Twenty patients with mild to moderate asthma were given 12, 24, 48 and 96 μg of formoterol or a matched placebo on separate days. The doses were administered using a randomised, cross-over, double-blind design. The effects on heart rate, blood pressure, electromechanical systole (QS2I), the electrocardiographic QTc interval, plasma potassium (K); blood glucose and FEV1 were assessed prior to, and for 9 h following each dose. Results: There was no difference between the maximum effects of formoterol 12 μg and placebo; the 24 μg dose significantly decreased plasma K (−0.2 mmol · l−1) and increased blood glucose (1.8 mmol · l−1) compared to placebo. The two highest doses affected most of the variables with the 96 μg dose being significantly different from placebo for all indices, heart rate (9 beats · min−1), systol BP (4 mmHg), diastolic BP (−3 mmHg), QS2I (−11 ms), QTc (17 ms), plasma K (−0.5 mmol · l−1) and blood glucose (2.6 mmol · l−1). All doses of formoterol increased FEV1. Conclusion: Although there were dose-dependent effects on the extrapulmonary measurements, only the effects at the highest dose may be of clinical significance.

Key words Formoterol Asthma 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • C. D. Burgess
    • 1
  • M. Ayson
    • 1
  • S. Rajasingham
    • 1
  • J. Crane
    • 1
  • G. Della Cioppa
    • 2
  • M. D. Till
    • 2
  1. 1.Department of Medicine, Wellington School of Medicine, PO Box 7343 Wellington South, Wellington, New Zealand, Tel.: +64 4 385 5999, Fax: +64 4 389 5427, e-mail: hbark@wnmeds.ac.nzNZ
  2. 2.Ciba-Geigy Ltd, Basel, SwitzerlandCH

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