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European Journal of Clinical Pharmacology

, Volume 53, Issue 5, pp 321–324 | Cite as

Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex

  • V. Piguet
  • J. Desmeules
  • P. Dayer
PHARMACODYNAMICS

Abstract

Objective: The analgesic efficacy of intravenous doses of acetaminophen (paracetamol) 0.5 g, 1 g and 2 g (administered as propacetamol) was assessed in 11 healthy subjects in a randomised, double-blind, placebo-controlled crossover study. The antinociceptive effect was assessed over 8 h by measurement of the nociceptive flexion reflex threshold (R-III) in response to selective transcutaneous electrical stimulations.

Results: After acetaminophen 0.5 g, R-III increased to a mean maximum of 23% over baseline values; after 1 g to 28%, and after 2 g to 40%. The AUC0–8 h of the analgesic effects and the AUC0–8 h of plasma concentrations closely correlated and were dose-dependent: r s = 0.37, for R-III and r s = 0.94, for the plasma concentrations. Intravenous acetaminophen exerted a dose-dependent central antinociceptive effect.

Key words Acetaminophen Analgesia 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • V. Piguet
    • 1
  • J. Desmeules
    • 1
  • P. Dayer
    • 1
  1. 1.Division of Clinical Pharmacology and Pain Center, University Hospital, CH-1211 Geneva 14, Switzerland Tel. +4122 372 99 32; Fax +4122 372 99 40CH

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