European Journal of Clinical Pharmacology

, Volume 51, Issue 6, pp 481–484

Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child

  • B. Rambeck
  • G. Kurlemann
  • S. R. G. Stodieck
  • T. W. May
  • U. Jürgens
PHARMACOKINETICS AND DISPOSITION

DOI: 10.1007/s002280050234

Cite this article as:
Rambeck, B., Kurlemann, G., Stodieck, S. et al. E J Clin Pharmacol (1997) 51: 481. doi:10.1007/s002280050234

Abstract

Objective: To investigate the transfer of lamotrigine in pregnancy and during lactation from a mother on lamotrigine treatment to her child.

Methods: Concentrations of lamotrigine were measured by high-pressure liquid chromatography in umbilical cord serum and in serum samples of the mother and her child as well as in the mother's milk during the first five postpartum months.

Results: In the child lamotrigine serum concentrations (up to 2.8 μg ml−1) comparable to those usually achieved in active treatment with lamotrigine were found not only after birth, but also during lactation. A considerable amount of lamotrigine (2–5 mg per day) was excreted in breast milk. No adverse effects were seen in the child.

Conclusion: The transfer of lamotrigine taking place during pregnancy and lactation should not be neglected. In this case the child should be thoroughly observed for potential adverse effects.

Key words Lamotrigine Breast feeding; protein binding placental transfer neonatal drug metabolism 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • B. Rambeck
    • 1
  • G. Kurlemann
    • 2
  • S. R. G. Stodieck
    • 3
  • T. W. May
    • 1
  • U. Jürgens
    • 1
  1. 1.Department of Biochemistry, Gesellschaft für Epilepsieforschung, Maraweg 13, D-33546 Bielefeld, GermanyDE
  2. 2.Department of Pediatrics, University of Münster, Münster, GermanyDE
  3. 3.Department of Neurology, University of Münster, Münster, GermanyDE

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