European Journal of Clinical Pharmacology

, Volume 51, Issue 5, pp 367–371

Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever

  • E. Autret
  • J. Reboul-Marty
  • B. Henry-Launois
  • C. Laborde
  • S. Courcier
  • J. M. Goehrs
  • G. Languillat
  • R. Launois
Pharmacodynamics

Abstract

Objective

We compared efficacy and impact on the comfort of ibuprofen (7.5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6–24 months in an open, randomised study with three parallel groups.

Methods

The main criterion for efficacy was area under the curve (AUC) of percentage temperature reduction. Comfort was assessed on scores depending on general behaviour and degree of relief. General behaviour was assessed on a verbal scale and on a visual analogue scale (VAS) and the degree of relief was assessed in relation to baseline on a verbal scale.

Results

The efficacy of ibuprofen was better than that of aspirin or paracetamol. In spite of more adverse events, the comfort scores were significantly in favour of ibuprofen 6 h after the first dose of treatment.

Key words

Ibuprofen Fever Paracetamol Aspirin Child Comfort 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Arrowsmith JB, Kennedy DL, Kuritsky JN, Faich GA (1987) National patterns of aspirin use and Reye’s syndrome reporting. United States 1980 to 1985. Paediatrics 79: 858–863Google Scholar
  2. 2.
    Autret E, Breart G, Jonville AP, Courcier S, Lassale C, Goehrs JM (1994) Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics. Eur J Clin Pharmacol 46: 197–201PubMedGoogle Scholar
  3. 3.
    Kauffman RE, Sawyer LA, Scheinbaum ML (1992) Antipyretic efficacy of ibuprofen vs acetaminophen. Am J Dis Child 14: 622–625Google Scholar
  4. 4.
    Makela AL, Lempiainen M, Yliijoki H (1981) Ibuprofen levels in serum and synovial fluid. Scand J Rheumatol 39: 15–17CrossRefGoogle Scholar
  5. 5.
    McGrath PJ, Johnson G, Goodman JT, Schillinger J, Dunn J,Chapman JA (1985) CHEOPS: a behavioral scale for rating postoperative pain in children. In: Fields HL, Eubner R, Cervero F (eds) Advances in pain research and therapy 9. Raven Press, New York ppGoogle Scholar
  6. 6.
    Nahata MC, Powell DA, Durrell DE, Miller MA, Gupta N (1992) Efficacy of ibuprofen in pediatric patients with fever. Int J Clin Pharm Ther Toxicol 30: 94–96Google Scholar
  7. 7.
    Rahwan GL, Rahwan RG (1986) Aspirin and Reye’s syndrome: the change in prescribing habits of health professionals. Drug Intell Clin Pharm 20: 143–145PubMedGoogle Scholar
  8. 8.
    Sidler J, Frey B, Baerlocher K (1990) A double-blind comparison of ibuprofen and paracetamol in juvenile pyrexia. Br J Clin Pathol 44 (Suppl 70): 22–25Google Scholar
  9. 9.
    Temple AR (1982) Committee on infectious diseases: aspirin and Reye’s syndrome. Paediatrics 69: 810–812Google Scholar
  10. 10.
    WalsonPD, Galletta G, Braden NJ, Alexander L (1989) Ibuprofen, acetaminophen and placebo treatment of febrile children. Clin Pharmacol Ther 9–17Google Scholar
  11. 11.
    Walson PD, Galletta G, Chomilo F, Braden NJ, Alexander L (1992) Comparison of multidose ibuprofen and acetaminophen theraphy in febrile children. Am J Dis Child 146: 626–632PubMedGoogle Scholar
  12. 12.
    Wilson JT, Don Brown R, Kearns GL, et al. (1991) Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children. J Pediatr 119: 803–811PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • E. Autret
    • 1
  • J. Reboul-Marty
    • 2
  • B. Henry-Launois
    • 3
  • C. Laborde
    • 4
  • S. Courcier
    • 4
  • J. M. Goehrs
    • 4
  • G. Languillat
    • 2
  • R. Launois
    • 2
  1. 1.Clinical Pharmacology DepartmentBretonneau HospitalTours CedexFrance
  2. 2.Faculty of Medicine of BobignyParis XIII UniversityBobigny CedexFrance
  3. 3.Issy-les-MoulineauxFrance
  4. 4.Boots PharmaCourbevoieFrance

Personalised recommendations