European Journal of Clinical Pharmacology

, Volume 51, Issue 2, pp 145–147

Diminished effect of etidronate in vitamin D deficient osteopenic postmenopausal women

  • J. C. Koster
  • W. H. L. Hackeng
  • H. Mulder


Objective: The effects of vitamin D deficiency in osteopenic postmenopausal women treated with intermittent cyclical etidronate have been studied. Bone mass and biochemical parameters as bone markers were measured before and after one year of therapy with intermittent cyclical etidronate.


In 30 patients without vitamin D deficiency, bone mass in the lumbal spine and femoral neck was significantly increased compared to 28 vitamin D deficient patients. After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change.


It is worthwhile measuring serum vitamin D before starting etidronate therapy and, in case of deficiency, to give vitamin D.

Key words Etidronate Vitamin D deficiency; postmenopausal women osteoporosis 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. C. Koster
    • 1
  • W. H. L. Hackeng
    • 2
  • H. Mulder
    • 3
  1. 1.Medisch Onderzoekcentrum Good Clinical Practice, Groot Hertoginnelaan 34, NL-2517 EH Den Haag, The NetherlandsNL
  2. 2.Praktijk voor laboratoriumdiagnostiek, Burg. Van de Minnelaan 3, NL-3211 AE Geervliet, The NetherlandsNL
  3. 3.Medisch Onderzoekcentrum Good Clinical Practice, Walenburgerweg 33, NL-3039 AC Roterdam, The NetherlandsNL

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