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European Journal of Clinical Pharmacology

, Volume 50, Issue 3, pp 241–244 | Cite as

Stereoselective pharmacokinetics of mefloquine in young children

  • A. Bourahla
  • C. Martin
  • F. Gimenez
  • V. Singhasivanon
  • P. Attanath
  • A. Sabchearon
  • T. Chongsuphajaisiddhi
  • R. Farinotti
PHARMACOKINETICS AND DISPOSITION

Abstract

Objective: the stereospecificity of mefloquine pharmacokinetics in children has been investigated.

Patients:

Twelve children aged 6 to 24 months were treated for uncomplicated falciparum malaria with a single oral dose of 25 mg⋅kg−1 racemic mefloquine in combination with sulfadoxine and pyrimethamine.

Methods:

concentrations of mefloquine enantiomers were determined using a coupled achiral-chiral chromatographic system. Pharmacokinetic parameters were calculated using model-independent analysis.

Results:

Maximum plasma concentrations, areas under the curve and apparent plasma elimination half-lives were higher for the (−) enantiomer than its antipode. In contrast, the apparent volume of distribution (V/f) and total clearance (Cl/f) values were higher for the (+) enantiomer.

Conclusion:

the stereoselectivity of mefloquine pharmacokinetics is similar to that observed in adults.

Key words Mefloquine Children; enantiomer pharmacokinetics stereoselectivity 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. Bourahla
    • 1
  • C. Martin
    • 1
  • F. Gimenez
    • 1
  • V. Singhasivanon
    • 3
  • P. Attanath
    • 3
  • A. Sabchearon
    • 3
  • T. Chongsuphajaisiddhi
    • 3
  • R. Farinotti
    • 2
  1. 1.Hôpital Pitie Salpetriere Service Pharmacie 47, boulevard de l′hôpital F-75651 Paris Cedex 13, FranceFR
  2. 2.Faculté de Pharmacie, Pharmacie Clinique, Chatenay Malabry, FranceFR
  3. 3.Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, ThailandTH

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