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Influence of renal failure on cytochrome P450 activity in hypertensive patients using a “cocktail” of antipyrine and nifedipine

  • V. L. Lanchote
  • W. C. Ping
  • S. R. C. J. Santos
PHARMACOKINETICS AND DISPOSITION

Abstract.

Objective. Two substrates were coadministered in a “cocktail” approach to evaluate the contribution of renal failure to drug oxidation.

Patients.

Nineteen hypertensive patients, nine of them with chronic renal failure (CLCR 38.9 vs 102.3 ml⋅min−1⋅1.73 m−2), were investigated after peroral administration of a combination of antipyrine (500 mg, in capsules) and nifedipine (10 mg, in Oxcord capsules) in the morning after an overnight fast.

Results.

This “cocktail” approach made it possible to characterize in vivo the activities of different forms of cytochrome P450 in a single-study protocol using the total clearance of nifedipine and clearance for production of 3-hydroxymethylantipyrine (HMA), 4-hydroxyantipyrine (OHA) and norantipyrine (NORA). With this “cocktail” approach (antipyrine plus nifedipine), we can suggest a selective effect on the activities of cytochrome P450 forms associated with the formation of dehydronifedipine (P450 III A4) and of NORA in patients with mild renal failure under long-term antihypertensive therapy.

Key words Antipyrine-nifedipine cocktail Renal failure; pharmacokinetics patients cytochrome P450 activity 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • V. L. Lanchote
    • 1
  • W. C. Ping
    • 2
  • S. R. C. J. Santos
    • 3
  1. 1.Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilBR
  2. 2.University Hospital, University of São Paulo, São Paulo, BrazilBR
  3. 3.44 Dr. E. de Carvalho Aguiar Avenue, Advanced Center of Clinical Pharmacology and Therapeutics, Research Laboratory, First Floor, Heart Institute, University of São Paulo, São Paulo, 05403-000, BrazilBR

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