European Journal of Clinical Pharmacology

, Volume 56, Issue 12, pp 865–871

An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers

  • Z. Shamsi
  • S. Kimber
  • I. Hindmarch
Pharmacodynamics

DOI: 10.1007/s002280000257

Cite this article as:
Shamsi, Z., Kimber, S. & Hindmarch, I. Eur J Clin Pharmacol (2001) 56: 865. doi:10.1007/s002280000257

Abstract

Objective: The cognitive and psychomotor effects of 2.5, 5 and 10 mg cetirizine, a second-generation H1 receptor antagonist, were compared with loratadine 10, 20 and 40 mg, promethazine 25 mg and placebo in 24 healthy volunteers in a double-blind, randomised cross-over study. Methods: Following each dose, subjects were required to perform a series of tests of cognitive function and psychomotor performance at 1.5, 3 and 6 h post-dose. The test battery consisted of critical flicker fusion (CFF), choice reaction time (CRT), compensatory tracking task (CTT) and assessment of subjective sedation (LARS). Results: Cetirizine and loratadine at all doses tested were not significantly different from placebo in any of the tests used. However, as expected for a verum, all measures with the exception of CTT were significantly disrupted by promethazine (P<0.05). Promethazine caused a reduction in CFF threshold at all test points; these differences were significant at 3 h and 6 h post-dose (P<0.05). There was also a significant increase in total reaction time at 3 h post-promethazine administration. Subjective reports of sedation were significantly greater following the administration of promethazine at all time points (P<0.05). Conclusions: These results allow the conclusion that cetirizine at its recommended therapeutic dose of 10 mg is demonstrably free from disruptive effects on aspects of psychomotor and cognitive function in a study where the psychometric assessments have been shown to be sensitive to impairment, as evidenced by the effects of the positive control, promethazine 25 mg.

Antihistamines Sedation Cognition 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Z. Shamsi
    • 1
  • S. Kimber
    • 1
  • I. Hindmarch
    • 1
  1. 1.HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford, GU2 5XP, United KingdomUK

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