Advertisement

European Journal of Clinical Pharmacology

, Volume 76, Issue 1, pp 127–129 | Cite as

Pharmacokinetics of cefoperazone/sulbactam in plasma and cerebrospinal fluid in patients with intraventricular hemorrhage after external ventricular drains

  • Liang Meng
  • Lingti Kong
  • Chenchen Wu
  • Benquan Qi
  • Xiaofei WuEmail author
Letter to the Editor
  • 63 Downloads

External ventricular drains (EVDs) are frequently placed to monitor intracranial pressure and relieve acute hydrocephalus in patients with intraventricular hemorrhage (ICH). However, the high incidence of infection remains a major complication, resulting in a significant increase in cost, hospital stay, morbidity, and mortality [1, 2, 3].

The infection complications of ICH caused by Gram-negative bacteria have shown an alarming increase in antibiotic resistances, and multidrug-resistant acinetobacter baumannii (MRAB) infections are getting common [4, 5]. At present, cefoperazone/sulbactam combined with meropenem is widely used in the treatment of MRAB [6, 7]; the clinical efficacy of this combination therapy has been recognized [8, 9].

We have studied the pharmacokinetics of meropenem in plasms/cerebrospinal fluid (CSF), which could provide a theoretical basis for the initial meropenem dose design in ICH patients [10]. But very few studies have been conducted on the pharmacokinetics...

Notes

Funding information

This study was financially supported by the Research Innovation Program for College Graduates of Bengbu Medical College (Byycx1761 and Byycxz1833) and Natural Science Foundation of Anhui (1708085QH208).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interests.

References

  1. 1.
    Dos Santos SC, Fortes Lima TT, Lunardi LW, Stefani MA (2017) External ventricular drain-related infection in spontaneous intracerebral hemorrhage. World Neurosurg 99:580–583CrossRefGoogle Scholar
  2. 2.
    Hagel S, Bruns T, Pletz MW, Engel C, Kalff R, Ewald C (2014) External ventricular drain infections: risk factors and outcome. Interdiscip Perspect Infect Dis 2014:708531CrossRefGoogle Scholar
  3. 3.
    Peter S, Roman B, Marjan Z (2016) External ventricular drainage infections: a single-centre experience on 100 cases. J Neurol Neurophysiol 7:392CrossRefGoogle Scholar
  4. 4.
    Sam JE, Lim CL, Sharda P, Wahab NA (2018) The organisms and factors affecting outcomes of external ventricular drainage catheter-related ventriculitis: a Penang Experience. Asian J Neurosurg 13:250–257CrossRefGoogle Scholar
  5. 5.
    Yadegarynia D, Gachkar L, Fatemi A, Zali A, Nobari N, Asoodeh M, Parsaieyan Z (2014) Changing pattern of infectious agents in postneurosurgical meningitis. Caspian J Intern Med 5:170–175PubMedPubMedCentralGoogle Scholar
  6. 6.
    Chen BY, He LX, Hu BJ (2012) Consensus of the Chinese specialists for diagnosis, treatment & control of Acinetobacter baumannii infection. Zhonghua Yi Xue Za Zhi 92:76–85PubMedGoogle Scholar
  7. 7.
    Deveci A, Coban AY, Acicbe O, Tanyel E, Yaman G, Durupinar B (2012) In vitro effects of sulbactam combinations with different antibiotic groups against clinical Acinetobacter baumannii isolates. J Chemother 24:247–252CrossRefGoogle Scholar
  8. 8.
    Chen F, Wang L, Wang M, Xie Y, Xia X, Li X, Liu Y, Cao W, Zhang T, Li P, Yang M (2018) Genetic characterization and in vitro activity of antimicrobial combinations of multidrug-resistant Acinetobacter baumannii from a general hospital in China. Oncol Lett 15:2305–2315PubMedGoogle Scholar
  9. 9.
    Niu T, Luo Q, Li Y, Zhou Y, Yu W, Xiao Y (2019) Comparison of tigecycline or cefoperazone/sulbactam therapy for bloodstream infection due to carbapenem-resistant Acinetobacter baumannii. Antimicrob Resist Infect Control 8:52CrossRefGoogle Scholar
  10. 10.
    Xu H, Kong L, Wu C, Xu B, Wu X (2019) Pharmacokinetics of meropenem in plasma and cerebrospinal fluid in patients with intraventricular hemorrhage after lateral ventricle drainage. Eur J Clin Pharmacol 75:595–597CrossRefGoogle Scholar
  11. 11.
    Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31–41CrossRefGoogle Scholar
  12. 12.
    Wang Q, Wu Y, Chen B, Zhou J (2015) Drug concentrations in the serum and cerebrospinal fluid of patients treated with cefoperazone/sulbactam after craniotomy. BMC Anesthesiol 15:33CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Emergency Internal MedicineThe First Affiliated Hospital of Bengbu Medical CollegeBengbuChina
  2. 2.Department of PharmacyThe First Affiliated Hospital of Bengbu Medical CollegeBengbuChina
  3. 3.Department of EndocrinologyThe First Affiliated Hospital of Bengbu Medical CollegeBengbuChina

Personalised recommendations