European Journal of Clinical Pharmacology

, Volume 76, Issue 1, pp 127–129 | Cite as

Pharmacokinetics of cefoperazone/sulbactam in plasma and cerebrospinal fluid in patients with intraventricular hemorrhage after external ventricular drains

  • Liang Meng
  • Lingti Kong
  • Chenchen Wu
  • Benquan Qi
  • Xiaofei WuEmail author
Letter to the Editor

External ventricular drains (EVDs) are frequently placed to monitor intracranial pressure and relieve acute hydrocephalus in patients with intraventricular hemorrhage (ICH). However, the high incidence of infection remains a major complication, resulting in a significant increase in cost, hospital stay, morbidity, and mortality [1, 2, 3].

The infection complications of ICH caused by Gram-negative bacteria have shown an alarming increase in antibiotic resistances, and multidrug-resistant acinetobacter baumannii (MRAB) infections are getting common [4, 5]. At present, cefoperazone/sulbactam combined with meropenem is widely used in the treatment of MRAB [6, 7]; the clinical efficacy of this combination therapy has been recognized [8, 9].

We have studied the pharmacokinetics of meropenem in plasms/cerebrospinal fluid (CSF), which could provide a theoretical basis for the initial meropenem dose design in ICH patients [10]. But very few studies have been conducted on the pharmacokinetics...


Funding information

This study was financially supported by the Research Innovation Program for College Graduates of Bengbu Medical College (Byycx1761 and Byycxz1833) and Natural Science Foundation of Anhui (1708085QH208).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interests.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Emergency Internal MedicineThe First Affiliated Hospital of Bengbu Medical CollegeBengbuChina
  2. 2.Department of PharmacyThe First Affiliated Hospital of Bengbu Medical CollegeBengbuChina
  3. 3.Department of EndocrinologyThe First Affiliated Hospital of Bengbu Medical CollegeBengbuChina

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