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Spanish list of potentially inappropriate drugs in the elderly (ES-PIA project)

  • Magali Gonzalez-Colaço HarmandEmail author
  • Ana María Aldea-Perona
  • Carlos Boada-Fernández del Campo
  • Almudena Areosa-Sastre
  • Consuelo Rodríguez-Jiménez
  • Marcelino García Sánchez-Colomer
  • Eduardo Fernández Quintana
  • Mercedes Plasencia-Nuñez
  • Paula Masiero-Aparicio
  • Candelaria Grillo-Grillo
  • Andrés Orellana-Mobilli
  • Mar García Sáiz
  • on behalf of the ES-PIA project group
  • Carmen Duarte Diéguez
  • Mercedes Hornillos Calvo
  • Juan Antonio Avellana Zaragoza
  • Nicolás Martínez Velilla
  • Domingo de Guzmán Pérez Hernández
  • Mario Ruiz González
  • Encarnación Blanco Reina
  • Carmen Asensio Ostos
  • Ana Peiró
  • Lourdes Cabrera García
  • Fuensanta Hortigüela Moro
  • Herlinda Pérez Alayón
  • Iriana Espárrago García
  • Javier Santana Quilez
  • Javier Alonso Ramírez
  • Carlos Fernández Oropesa
  • Mª José López Varona
  • Mª Teresa Acín Gerico
  • Emilio Sanz Alvarez
  • María Ángeles Martín de la Sierra
  • María José Peñalver
  • Teresa Falomir Gómez
  • Jesús Ruiz Salazar
  • Gabriela Elizondo Rivas
  • Edmundo Rey Rodríguez
Pharmacoepidemiology and Prescription

Abstract

Purpose

In the last decades, different criteria have been developed for detecting inappropriate prescription in older patients. In Spain, translations and adaptations of international lists are available but it would be necessary a national list which could cope with the peculiarities of our health system, existing pharmaceutical market, and prescription habits. We propose in this project the creation of a Spanish potentially inappropriate drugs list which could be applicable in our clinical scenario.

Methods

We use a Delphi method involving 25 experts from different backgrounds (Clinical Pharmacology, Geriatrics, Rational Use of Drugs and Pharmacy, Primary Care and Pharmacoepidemiology, and Pharmacovigilance) that were asked to participate in two-round questionnaires.

For analysis, current recommendations of Worth and Pigni were applied, and every statement was classified into one of three groups: strong, moderate, or low agreement. Statements with strong agreement were accepted to be part of the inadequate prescription list. Moderate agreement statements were selected to enter the second questionnaire, and statements with low agreement were further analyzed to determine if it was due to heterogeneity or due to dispersion in the answers.

Results

The first questionnaire consisted of 160 proposed sentences, of which 106 reached a high agreement, 32 a moderate agreement, and 22 a low agreement. All sentences proposed in the second questionnaire reached a strong agreement. The total accepted sentences were 138.

Conclusions

We offer a list of inadequate prescription in older patients adapted to the Spanish pharmacopeia and according to the prescription habits in our environment.

Keywords

Older patients Inadequate prescription Potentially inappropriate 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Magali Gonzalez-Colaço Harmand
    • 1
    Email author
  • Ana María Aldea-Perona
    • 1
    • 2
    • 3
  • Carlos Boada-Fernández del Campo
    • 4
  • Almudena Areosa-Sastre
    • 5
  • Consuelo Rodríguez-Jiménez
    • 4
  • Marcelino García Sánchez-Colomer
    • 6
  • Eduardo Fernández Quintana
    • 6
  • Mercedes Plasencia-Nuñez
    • 7
  • Paula Masiero-Aparicio
    • 4
  • Candelaria Grillo-Grillo
    • 4
  • Andrés Orellana-Mobilli
    • 4
  • Mar García Sáiz
    • 1
    • 4
  • on behalf of the ES-PIA project group
  • Carmen Duarte Diéguez
  • Mercedes Hornillos Calvo
  • Juan Antonio Avellana Zaragoza
  • Nicolás Martínez Velilla
  • Domingo de Guzmán Pérez Hernández
  • Mario Ruiz González
  • Encarnación Blanco Reina
  • Carmen Asensio Ostos
  • Ana Peiró
  • Lourdes Cabrera García
  • Fuensanta Hortigüela Moro
  • Herlinda Pérez Alayón
  • Iriana Espárrago García
  • Javier Santana Quilez
  • Javier Alonso Ramírez
  • Carlos Fernández Oropesa
  • Mª José López Varona
  • Mª Teresa Acín Gerico
  • Emilio Sanz Alvarez
  • María Ángeles Martín de la Sierra
  • María José Peñalver
  • Teresa Falomir Gómez
  • Jesús Ruiz Salazar
  • Gabriela Elizondo Rivas
  • Edmundo Rey Rodríguez
  1. 1.UCICECUniversity Hospital of Canary IslandsLa LagunaSpain
  2. 2.Servei de Farmacologia clínicaHospital del MarBarcelonaSpain
  3. 3.IMIM (Institut Hospital del Mar d’Investigacions Mèdiques)BarcelonaSpain
  4. 4.Servicio de Farmacología ClínicaUniversity Hospital of Canary IslandsTenerifeSpain
  5. 5.Geriatric UnitUniversity Hospital of GetafeMadridSpain
  6. 6.Centro de Farmacovigilancia e Información Terapéutica de CanariasSanta Cruz de TenerifeSpain
  7. 7.Uso Racional del Medicamento y Control de la PrestaciónDirección General de Programas Asistenciales. Servicio Canario de la SaludTenerifeSpain

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