Applying DoTS adverse drug reactions classification to reports from hospital stimulated reporting
To the Editor
We want to report inhere the results of an evaluation of adverse drug reactions (ADRs) using the DoTS classification .
We have retrospectively applied the DoTS classification on all 251 ADRs prospectively collected in two internal medicine departments from Cluj-Napoca, Romania, during January 2010–July 2012 and registered into our database. The information available for evaluation was collected by review of medical charts, patient interviews, and discussion with attending physicians. Patients’ age, sex, alcohol intake, medical history, clinical and biological relevant data, ADRs description (including causality, seriousness, treatment and outcome, response to de-challenge and re-challenge, if performed), and information on suspected drugs (dose and treatment duration) were available. Only cases with at least possible causality relation were included in the present analysis. Causality was assessed with Karch-Lasagna  algorithm. For all the ADRs, the Rawlins and...
AF, NBB, AP, and AMA evaluated the cases according to the DoTS classification. AF and CM developed the study design. AF and CB were involved in acquisition, analysis, and interpretation of final data. CB and AF drafted the manuscript. All authors revised the paper critically for important intellectual content and provided the final approval of the version to be published; they also agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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