Comparison of effect of an increased dosage of vonoprazan versus vonoprazan plus lafutidine on gastric acid inhibition and serum gastrin

  • Takahiro Suzuki
  • Takuma Kagami
  • Takahiro Uotani
  • Mihoko Yamade
  • Yasushi Hamaya
  • Moriya Iwaizumi
  • Satoshi Osawa
  • Ken Sugimoto
  • Hiroaki Miyajima
  • Takahisa Furuta
Pharmacodynamics
  • 418 Downloads

Abstract

Background

Vonoprazan, a novel potassium-competitive acid blocker, elicits potent acid inhibition and hypergastrinemia at a dose of 20 mg. Its recommended maintenance dose for gastro-esophageal reflux disease is 10 mg, which is sometimes insufficient for preventing nocturnal acid breakthrough (NAB). Concomitant use of a histamine 2 receptor antagonist (H2RA) is effective for NAB. However, further acid inhibition by addition of H2RA has concern of hypergastrinemia again. Lafutidine (H2RA) is known to stimulate somatostatin release.

Aims

The aim of this study is to compare the levels of acid inhibition and serum gastrin attained by addition of lafutidine to vonoprazan 10 mg with levels after a dose increase of vonoprazan from 10 to 20 mg.

Methods

Thirteen healthy volunteers underwent 24-h intragastric pH monitoring and serum gastrin measurements on day 7 of three different regimens: vonoprazan 10 mg, vonoprazan 10 mg plus lafutidine 10 mg, and vonoprazan 20 mg.

Results

Median pH 4 holding time ratios (range) by vonoprazan 10 mg, vonoprazan 10 mg plus lafutidine 10 mg, and vonoprazan 20 mg were 82% (47–88%), 88% (76–93%), and 99% (95–100%) while those at nighttime from 10 p.m. to 8 a.m. were 94% (29–100%), 100% (95–100%), and 100%, respectively. The incidences of NAB with vonoprazan 10 mg, vonoprazan plus lafutidine, and vonoprazan 20 mg were 38, 8, and 0%, respectively. Respective serum gastrin levels were 420 (173–508), 323 (196–521), and 504 (400–812) pg/ml.

Conclusion

Addition of lafutidine 10 mg to vonoprazan 10 mg achieved sufficient acid inhibition, especially at nighttime, without further increase of serum gastrin levels.

Keywords

Potassium-competitive acid blocker Vonoprazan Lafutidine Histamine 2 receptor antagonist Intragastric pH 

Abbreviations

pH 4 HRT

pH > 4 holding time ratio

PPI

Proton pump inhibitor

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Takahiro Suzuki
    • 1
  • Takuma Kagami
    • 1
  • Takahiro Uotani
    • 2
  • Mihoko Yamade
    • 1
  • Yasushi Hamaya
    • 1
  • Moriya Iwaizumi
    • 3
  • Satoshi Osawa
    • 2
  • Ken Sugimoto
    • 1
  • Hiroaki Miyajima
    • 1
  • Takahisa Furuta
    • 4
  1. 1.First Department of MedicineHamamatsu University School of MedicineHamamatsuJapan
  2. 2.Department of Endoscopic and Photodynamic MedicineHamamatsu University School of MedicineHamamatsuJapan
  3. 3.Department of Laboratory MedicineHamamatsu University School of MedicineHamamatsuJapan
  4. 4.Center for Clinical ResearchHamamatsu University School of MedicineHamamatsuJapan

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