Use of antimigraine medications and information needs during pregnancy and breastfeeding: a cross-sectional study among 401 Norwegian women
- 558 Downloads
Migraine is highly prevalent among women of fertile age. The main objectives of this study were to describe the prevalence and patterns of use of antimigraine medications during pregnancy and breastfeeding and to identify maternal and migraine-related factors associated with medication use during pregnancy.
The study is a cross-sectional internet-based survey among pregnant women and new mothers with migraine conducted in Norway from October 1, 2013 to February 1, 2014. Descriptive statistics were used to explore patterns of medication use, and logistic regression analysis was performed to examine the association between maternal socio-demographic and migraine-related factors and use of antimigraine medications during pregnancy.
Of the total 401 respondents, 34.9 % were pregnant and 65.1 % had delivered within the last 18 months. The majority reported use of antimigraine medications during pregnancy (73.3 %) and postpartum (64.8 %), yet less than a third considered their migraine to be optimally treated during pregnancy (31.7 %) and the breastfeeding period (27.2 %). The patterns of medication use markedly changed during pregnancy and postpartum. Women with moderate or severe migraine were more likely to use antimigraine medications during pregnancy compared to women with mild migraine.
Despite the fact that antimigraine medications were commonly used, the majority of the women felt that their migraine was suboptimally treated during pregnancy and postpartum. There was a decline in the use of medicines in pregnancy and postpartum, and the patterns of use markedly changed. Efforts to improve treatment of women with migraine during pregnancy and breastfeeding should be undertaken.
KeywordsMigraine Pregnancy Breastfeeding Drug therapy Information needs
The study was funded by a research grant from the Northern Norway Regional Health Authority (project ID 12165/SFP1248-15). Thanks to all the women who participated in the study, Tom Wilsgaard for advice and help with the statistical analyses, and Stefan Barfeld for the translation of the questionnaire into English. Thanks also to Abdelkader El Hasnaoui for the permission to use the MIGSEV scale and to Thibaud Freyd for the assistance with back-translation of the scale into French. We acknowledge the assistance of RELIS (www.tryggmammamedisin.no), the Norwegian Migraine Association (www.migrene.no), and the website administrators Siri von Krogh (www.altformamma.no) and Elisabeth Lofthus (www.mammanet.no) who all contributed to the recruitment process.
Contributions of authors
NMSA, SA, HN, and TGØ designed the questionnaire. NMSA and TGØ developed the electronic version of the questionnaire and were actively promoting the study and recruiting participants in social media. SA conducted the analyses and drafted the manuscript. HN aided in the analyses and interpretation of the data and contributed to revisions of the manuscript with important intellectual content. ACP aided in the development of the questionnaire and provided comments for the revision of the manuscript. All authors read and approved the final version of the manuscript.
Compliance with ethical standards
Conflict of interest
ACP has given lectures and presentations for Allergan, GlaxoSmithKline, MSD, Nycomed, and Pfizer from 1999 until 2014 and has occasionally participated in advisory boards for Allergan, Nycomed, and GlaxoSmithKline.
The other authors declare that they have no conflict of interest.
- 1.Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM, Serrano D, Lipton RB (2013) Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American migraine prevalence and prevention (AMPP) study. Headache 53:1278–1299. doi:10.1111/head.12150 CrossRefPubMedGoogle Scholar
- 7.Axelsdottir TO, Sigurdsson EL, Gudmundsdottir AM, Kristjansdottir H, Sigurdsson JA (2014) Drug use during early pregnancy: cross-sectional analysis from the childbirth and health study in primary Care in Iceland. Scand J Prim Health Care 32:139–145. doi:10.3109/02813432.2014.965884 CrossRefPubMedPubMedCentralGoogle Scholar
- 20.Hämeen-Anttila K, Nordeng H, Kokki E, Jyrkkä J, Lupattelli A, Vainio K, Enlund H (2014) Multiple information sources and consequences of conflicting information about medicine use during pregnancy: a multinational internet-based survey. J Med Internet Res 16:e60. doi:10.2196/jmir.2939 CrossRefPubMedPubMedCentralGoogle Scholar
- 27.StatBank Norway (2015) Table 08921: Persons 16 years and older, by sex, age and level of education. Numbers and percent (C). Statistics Norway https://www.ssb.no/statistikkbanken. Accessed 02 January 2016
- 28.Medical Birth Registry of Norway (2015) Standard statistics. http://statistikkbank.fhi.no/mfr/. Accessed 02 January 2016
- 38.Norwegian Media Barometer (2014) Table 04519: Percentage internet users and minutes used for internet an average day, by sex and education. Statistics Norway. https://www.ssb.no/statistikkbanken. Accessed 04 March 2016