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European Journal of Clinical Pharmacology

, Volume 70, Issue 3, pp 361–367 | Cite as

Prevalence, risk factors and main features of adverse drug reactions leading to hospital admission

  • Consuelo PedrósEmail author
  • Beatriz Quintana
  • Mireia Rebolledo
  • Núria Porta
  • Antoni Vallano
  • Josep Maria Arnau
Pharmacoepidemiology and Prescription

Abstract

Purpose

To assess the prevalence of hospital admission related to adverse drug reactions (ADRs) in a third-level hospital, to analyse the associated factors, and to describe the reactions and the drugs involved.

Methods

A cross-sectional study was conducted for a 120-day period. Patients that were urgently hospitalized entered the study. The primary endpoint was the ADR-related urgent admission. A descriptive analysis of demographic, clinical, and drug-related variables was performed. The association between the likelihood of urgent admission due to ADRs and age, gender, and number of drugs used was analysed. A descriptive analysis of the suspected drugs and the reactions in ADR-related admissions was performed.

Results

Overall, 186 out of 4,403 hospital admissions were due to ADRs (prevalence: 4.2 % [95 % CI 3.7–4.8 %]). Age (≥65 years: OR 1.59 [95 % CI 1.10–2.29]) and number of drugs used at the time of admission (3–5 drugs: OR 5.07 [95 % CI 2.71–9.59]; 6–9 drugs: OR 5.90 [95 % CI 3.16–11.0]; ≥10 drugs: OR 8.94 [95 % CI 4.73–16.89]), but not gender, were identified as independent factors associated with ADR-related hospitalization. The overall in-hospital stay for patients admitted with ADRs amounted to 1,785 days. The ADRs were mainly type A reactions (92 %). Acute renal failure related to renin-angiotensin system inhibitors, haemorrhage due to anticoagulants, and upper gastrointestinal bleeding related to antiplatelet drugs and/or non-steroidal anti-inflammatory drugs were the most frequent.

Conclusion

Over 4 % of urgent hospitalizations are caused by ADRs, which are dose-related and predictable in more than 90 % of cases. The main risk factors are advanced age and polypharmacy.

Keywords

Pharmacovigilance Adverse drug reaction reporting systems Drug toxicity Hospitalization Risk factors 

Notes

Acknowledgments

The authors would like to thank the staff of the Admissions Unit of Bellvitage University Hospital, who on a daily-basis, and always on time, provided us with the daily list of urgent admissions.

Conflict of interest

No sources of funding were used to assist in the development of this study. The authors declare that they have no conflicts of interest.

Supplementary material

228_2013_1630_MOESM1_ESM.doc (58 kb)
ESM 1 (DOC 57 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Consuelo Pedrós
    • 1
    • 2
    Email author
  • Beatriz Quintana
    • 1
    • 2
  • Mireia Rebolledo
    • 1
    • 2
  • Núria Porta
    • 2
    • 3
  • Antoni Vallano
    • 1
    • 2
    • 4
  • Josep Maria Arnau
    • 1
    • 2
    • 3
    • 4
  1. 1.Clinical Pharmacology ServiceBellvitge University HospitalBarcelonaSpain
  2. 2.Bellvitge Biomedical Research Institute (IDIBELL)BarcelonaSpain
  3. 3.Clinical Trials Unit (UCICEC-CAIBER)Bellvitge Biomedical Research Institute (IDIBELL)BarcelonaSpain
  4. 4.Department of Pathology and Experimental TherapeuticsUniversity of BarcelonaBarcelonaSpain

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