European Journal of Clinical Pharmacology

, Volume 70, Issue 3, pp 361–367

Prevalence, risk factors and main features of adverse drug reactions leading to hospital admission

  • Consuelo Pedrós
  • Beatriz Quintana
  • Mireia Rebolledo
  • Núria Porta
  • Antoni Vallano
  • Josep Maria Arnau
Pharmacoepidemiology and Prescription

DOI: 10.1007/s00228-013-1630-5

Cite this article as:
Pedrós, C., Quintana, B., Rebolledo, M. et al. Eur J Clin Pharmacol (2014) 70: 361. doi:10.1007/s00228-013-1630-5

Abstract

Purpose

To assess the prevalence of hospital admission related to adverse drug reactions (ADRs) in a third-level hospital, to analyse the associated factors, and to describe the reactions and the drugs involved.

Methods

A cross-sectional study was conducted for a 120-day period. Patients that were urgently hospitalized entered the study. The primary endpoint was the ADR-related urgent admission. A descriptive analysis of demographic, clinical, and drug-related variables was performed. The association between the likelihood of urgent admission due to ADRs and age, gender, and number of drugs used was analysed. A descriptive analysis of the suspected drugs and the reactions in ADR-related admissions was performed.

Results

Overall, 186 out of 4,403 hospital admissions were due to ADRs (prevalence: 4.2 % [95 % CI 3.7–4.8 %]). Age (≥65 years: OR 1.59 [95 % CI 1.10–2.29]) and number of drugs used at the time of admission (3–5 drugs: OR 5.07 [95 % CI 2.71–9.59]; 6–9 drugs: OR 5.90 [95 % CI 3.16–11.0]; ≥10 drugs: OR 8.94 [95 % CI 4.73–16.89]), but not gender, were identified as independent factors associated with ADR-related hospitalization. The overall in-hospital stay for patients admitted with ADRs amounted to 1,785 days. The ADRs were mainly type A reactions (92 %). Acute renal failure related to renin-angiotensin system inhibitors, haemorrhage due to anticoagulants, and upper gastrointestinal bleeding related to antiplatelet drugs and/or non-steroidal anti-inflammatory drugs were the most frequent.

Conclusion

Over 4 % of urgent hospitalizations are caused by ADRs, which are dose-related and predictable in more than 90 % of cases. The main risk factors are advanced age and polypharmacy.

Keywords

Pharmacovigilance Adverse drug reaction reporting systems Drug toxicity Hospitalization Risk factors 

Supplementary material

228_2013_1630_MOESM1_ESM.doc (58 kb)
ESM 1(DOC 57 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Consuelo Pedrós
    • 1
    • 2
  • Beatriz Quintana
    • 1
    • 2
  • Mireia Rebolledo
    • 1
    • 2
  • Núria Porta
    • 2
    • 3
  • Antoni Vallano
    • 1
    • 2
    • 4
  • Josep Maria Arnau
    • 1
    • 2
    • 3
    • 4
  1. 1.Clinical Pharmacology ServiceBellvitge University HospitalBarcelonaSpain
  2. 2.Bellvitge Biomedical Research Institute (IDIBELL)BarcelonaSpain
  3. 3.Clinical Trials Unit (UCICEC-CAIBER)Bellvitge Biomedical Research Institute (IDIBELL)BarcelonaSpain
  4. 4.Department of Pathology and Experimental TherapeuticsUniversity of BarcelonaBarcelonaSpain

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