European Journal of Clinical Pharmacology

, Volume 70, Issue 2, pp 135–140

Putative effects of potentially anti-angiogenic drugs in rheumatic diseases

  • Nicola Maruotti
  • Francesco Paolo Cantatore
  • Domenico Ribatti
Review Article

DOI: 10.1007/s00228-013-1605-6

Cite this article as:
Maruotti, N., Cantatore, F.P. & Ribatti, D. Eur J Clin Pharmacol (2014) 70: 135. doi:10.1007/s00228-013-1605-6


A role for angiogenesis has been described in several rheumatic diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, systemic sclerosis, systemic lupus erythematosus, vasculitides, and osteoarthritis, leading to the possibility that angiogenesis inhibition may be an additional useful therapeutic arm. While the role of anti-angiogenic therapy in rheumatoid arthritis has received attention, it is conceivable that the inhibition of pathological angiogenesis may also be a useful therapeutical approach in other rheumatic diseases. Numerous compounds, such as, for example, various interleukins, antibodies directed against angiogenic factors, peptides, estrogen metabolites, disease-modifying anti-rheumatic drugs, have been found to have anti-angiogenic properties. However, additional research is needed to obtain a clear understanding of the pathogenic mechanism of angiogenesis and the potential applications of anti-angiogenic therapy in rheumatic diseases.


Angiogenesis Arthritis Rheumatic disease Therapy 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Nicola Maruotti
    • 1
  • Francesco Paolo Cantatore
    • 1
    • 3
  • Domenico Ribatti
    • 2
  1. 1.Rheumatology Clinic, Department of Medical and Surgical SciencesUniversity of Foggia Medical SchoolFoggiaItaly
  2. 2.Department of Basic Medical Sciences, Neurosciences and Sensory OrgansUniversity of Bari Medical SchoolBariItaly
  3. 3.Rheumatology Clinic “Mario Carrozzo” “D’Avanzo” HospitalFoggiaItaly

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