Gamma-hydroxybutyrate (GHB) and topiramate—clinically relevant drug interaction suggested by a case of coma and increased plasma GHB concentration
Letter to the Editors
First Online:
Received:
Accepted:
Keywords
Topiramate Cluster Headache Ethosuximide Sodium Oxybate Myoclonic Jerk
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Notes
Conflicts of Interest
None.
References
- 1.Khatami R, Tartarotti S, Siccoli MM, Bassetti CL, Sandor PS (2011) Long-term efficacy of sodium oxybate in 4 patients with chronic cluster headache. Neurology 77(1):67–70PubMedCrossRefGoogle Scholar
- 2.Entholzner E, Mielke L, Pichlmeier R, Weber F, Schneck H (1995) EEG changes during sedation with gamma-hydroxybutyric acid. Der Anaesthesist 44(5):345–350PubMedCrossRefGoogle Scholar
- 3.Brenneisen R, Elsohly MA, Murphy TP, Passarelli J, Russmann S, Salamone SJ, Watson DE (2004) Pharmacokinetics and excretion of gamma-hydroxybutyrate (GHB) in healthy subjects. J Anal Toxicol 28(8):625–630PubMedCrossRefGoogle Scholar
- 4.Hechler V, Ratomponirina C, Maitre M (1997) gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide. J Pharmacol Exp Ther 281(2):753–760PubMedGoogle Scholar
Copyright information
© Springer-Verlag Berlin Heidelberg 2012