European Journal of Clinical Pharmacology

, Volume 68, Issue 7, pp 1095–1101 | Cite as

Association between multi-dose drug dispensing and drug treatment changes

  • Christina SjöbergEmail author
  • Henrik Ohlsson
  • Susanna M Wallerstedt
Pharmacoepidemiology and Prescription



To compare drug treatment changes in older hip fracture patients with and without multi-dose drug dispensing (MDD) after discharge from hospital.


Hip fracture patients (aged 65 years or older) for whom the same prescribing procedure was used at discharge and at the 6-month follow-up were extracted from two patient cohorts consecutively recruited in 2008 (n = 100) and 2009 (n = 99), respectively. Of these hip fracture patients, 107 patients used MDD and 47 used ordinary prescriptions (OP) throughout the study period. Drug treatment was registered at discharge and at the 6-month follow-up. Each drug was classified as changed (withdrawn, dosage adjusted or added) or unchanged. The association between MDD and changes in drug treatment was analysed with generalised estimating equations (GEE). Age, sex, cognition, year of study and type of drug (fall-risk-increasing, fracture-preventing or other) were included in the model.


A total of 1,980 drugs were prescribed at discharge and at the 6-month follow-up to the 154 patients. Of the 1,413 drugs prescribed via MDD, 597 (43%) drugs were unchanged. The corresponding figure for drugs prescribed via OP was 166 out of 567 (29%) prescribed drugs. Analysis with GEE revealed an odds ratio (95% confidence interval) of 1.66 (1.20–2.31) to 1.77 (1.38–2.27) for a drug to be classified as unchanged when prescribed via the MDD system.


MDD is associated with fewer changes in drug treatment compared with OP. Further studies of risks and benefits from this prescribing procedure are urged.


Prescribing Multi-dose drug dispensing Drug treatment Elderly 



The study was supported by the National Board of Health and Welfare. The funding source did not influence design, methods, subject recruitment, data collections, analysis, preparation of paper or the decision to submit the paper for publication.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Christina Sjöberg
    • 1
    Email author
  • Henrik Ohlsson
    • 2
    • 3
  • Susanna M Wallerstedt
    • 4
  1. 1.Department of GeriatricsSahlgrenska University Hospital/MölndalMölndalSweden
  2. 2.Centre for Primary Health Care ResearchLund University/Region Skåne, Skåne University HospitalMalmöSweden
  3. 3.Social Epidemiology, Department of Clinical Science, Faculty of MedicineLund UniversityMalmöSweden
  4. 4.Department of Clinical PharmacologySahlgrenska University HospitalGothenburgSweden

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