Suspected unexpected adverse effect of sugammadex: hypotension
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Cyclic oligosaccharides, cyclodextrins, are increasingly used in clinical practice . A chemically modified γ-cyclodextrin consisting of eight glucopyranose units, sugammadex, is used to reverse neuromuscular blockade induced with rocuronium and other aminosteroid neuromuscular agents. The mode of action of sugammadex is unique: chelation of aminosteroid agents . Human studies in healthy volunteers and patients indicate that sugammadex is well tolerated, but some adverse effects may occur. The most commonly reported adverse effect of sugammadex is dysgeusia . Other commonly reported adverse events are anesthetic complications, as well as uncommonly reported hypersensitivity reactions, unwanted awareness during anesthesia, and a rare case of anaphylaxis.
KeywordsFentanyl Enalapril Sevoflurane Rocuronium Marketing Authorization
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