European Journal of Clinical Pharmacology

, Volume 68, Issue 5, pp 899–900 | Cite as

Suspected unexpected adverse effect of sugammadex: hypotension

  • Merja Kokki
  • Mohamed Ali
  • Matti Turunen
  • Hannu Kokki
Letter to the Editors

Dear Editor

Cyclic oligosaccharides, cyclodextrins, are increasingly used in clinical practice [1]. A chemically modified γ-cyclodextrin consisting of eight glucopyranose units, sugammadex, is used to reverse neuromuscular blockade induced with rocuronium and other aminosteroid neuromuscular agents. The mode of action of sugammadex is unique: chelation of aminosteroid agents [2]. Human studies in healthy volunteers and patients indicate that sugammadex is well tolerated, but some adverse effects may occur. The most commonly reported adverse effect of sugammadex is dysgeusia [2]. Other commonly reported adverse events are anesthetic complications, as well as uncommonly reported hypersensitivity reactions, unwanted awareness during anesthesia, and a rare case of anaphylaxis.

In October 2010, a 33-years old Caucasian woman with normal body weight (54 kg; height 164 cm) was admitted to our day-case surgical unit for laparoscopic sterilization. In her medical history, she had arterial...


Fentanyl Enalapril Sevoflurane Rocuronium Marketing Authorization 
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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Merja Kokki
    • 1
  • Mohamed Ali
    • 1
  • Matti Turunen
    • 1
  • Hannu Kokki
    • 1
    • 2
  1. 1.Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of MedicineUniversity of Eastern FinlandKuopioFinland
  2. 2.Department of Anaesthesiology and Operative ServicesKuopio University HospitalKuopioFinland

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