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European Journal of Clinical Pharmacology

, Volume 68, Issue 5, pp 899–900 | Cite as

Suspected unexpected adverse effect of sugammadex: hypotension

  • Merja Kokki
  • Mohamed Ali
  • Matti Turunen
  • Hannu Kokki
Letter to the Editors

Dear Editor

Cyclic oligosaccharides, cyclodextrins, are increasingly used in clinical practice [1]. A chemically modified γ-cyclodextrin consisting of eight glucopyranose units, sugammadex, is used to reverse neuromuscular blockade induced with rocuronium and other aminosteroid neuromuscular agents. The mode of action of sugammadex is unique: chelation of aminosteroid agents [2]. Human studies in healthy volunteers and patients indicate that sugammadex is well tolerated, but some adverse effects may occur. The most commonly reported adverse effect of sugammadex is dysgeusia [2]. Other commonly reported adverse events are anesthetic complications, as well as uncommonly reported hypersensitivity reactions, unwanted awareness during anesthesia, and a rare case of anaphylaxis.

In October 2010, a 33-years old Caucasian woman with normal body weight (54 kg; height 164 cm) was admitted to our day-case surgical unit for laparoscopic sterilization. In her medical history, she had arterial...

Keywords

Fentanyl Enalapril Sevoflurane Rocuronium Marketing Authorization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Merja Kokki
    • 1
  • Mohamed Ali
    • 1
  • Matti Turunen
    • 1
  • Hannu Kokki
    • 1
    • 2
  1. 1.Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of MedicineUniversity of Eastern FinlandKuopioFinland
  2. 2.Department of Anaesthesiology and Operative ServicesKuopio University HospitalKuopioFinland

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