European Journal of Clinical Pharmacology

, Volume 66, Issue 6, pp 645–646 | Cite as

Very late relapse of dapsone-induced methaemoglobinemia

  • Guillaume Moulis
  • Haleh Bagheri
  • Jacques Saint Martory
  • Pascale Bernard
  • Jean-Louis Montastruc
Letter to the Editors


Dapsone Methaemoglobinemia 


  1. 1.
    Anonymous (2007) Dapsone. In: Sweetman SC (ed) Martindale—the complete drug reference, 35th ed. Pharmaceutical Press, London, pp 234–236Google Scholar
  2. 2.
    Coleman MD, Rhodes LE, Scott AK et al (1992) The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients. Br J Clin Pharmacol 34:244–249PubMedGoogle Scholar
  3. 3.
    Turner MD, Karlis V, Glickman RS (2007) The recognition, physiology, and treatment of medication-induced methemoglobinemia: a case-report. Anesth Prog 54:115–117CrossRefPubMedGoogle Scholar
  4. 4.
    MacDonald RD, MacGuigan MA (1997) Acute dapsone intoxication: a pediatric case-report. Pediatr Emerg Care 13:127–129CrossRefPubMedGoogle Scholar
  5. 5.
    Kramer P, Glader B, Li T (1972) Mechanism of methaemoglobin formation by diphenylsulphones. Biochem Pharmacol 21:1265–1274CrossRefPubMedGoogle Scholar
  6. 6.
    Curry S (1982) Methemoglobinemia. Ann Emerg Med 11:214–221CrossRefPubMedGoogle Scholar
  7. 7.
    Sharma N, Varma S (2003) Unusual life-threatening adverse drug effects with chloroquine in a young girl. J Postgrad Med 49:187PubMedGoogle Scholar
  8. 8.
    Cohen RJ, Sachs JR, Wicker DJ, Conrad ME (1968) Methemoglobinemia provoked by malaria prophylaxis in Vietnam. N Engl J Med 279:1127–1131PubMedCrossRefGoogle Scholar
  9. 9.
    Zuidema J, Hilbers-Modderman E, Merkus F (1986) Clinical pharmacokinetics of dapsone. Clin Pharmacokinet 11:299–315CrossRefPubMedGoogle Scholar
  10. 10.
    Mitra A, Thummel K, Kalhorn T, Kharasch E, Unadkat J, Slattery J (1995) Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. Clin Pharmacol Ther 58:556–566CrossRefPubMedGoogle Scholar
  11. 11.
    Coleman MD, Jacobus DP (1993) Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro. Biochem Pharmacol 45:1027–1033CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Guillaume Moulis
    • 1
    • 2
    • 5
  • Haleh Bagheri
    • 2
    • 5
  • Jacques Saint Martory
    • 3
  • Pascale Bernard
    • 4
  • Jean-Louis Montastruc
    • 2
  1. 1.Service de Médecine Interne, Centre Hospitalier Universitaire de ToulouseUniversité Paul-SabatierToulouseFrance
  2. 2.Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d’Informations sur le Médicament, Unité de Pharmacoépidémiologie EA 3696, Centre Hospitalier Universitaire de ToulouseUniversité de Toulouse, Faculté de MédecineToulouseFrance
  3. 3.Service de Médecine InterneCentre Hospitalier d ‘AlbiAlbiFrance
  4. 4.Service de PharmacieClinique de l’UnionSaint-Jean de l’UnionFrance
  5. 5.Service de Pharmacologie CliniqueFaculté de MédecineToulouseFrance

Personalised recommendations