European Journal of Clinical Pharmacology

, Volume 65, Issue 6, pp 627–633 | Cite as

SFINX—a drug-drug interaction database designed for clinical decision support systems

  • Ylva Böttiger
  • Kari Laine
  • Marine L. Andersson
  • Tuomas Korhonen
  • Björn Molin
  • Marie-Louise Ovesjö
  • Tuire Tirkkonen
  • Anders Rane
  • Lars L. Gustafsson
  • Birgit EiermannEmail author
Pharmacoepidemiology and Prescription



The aim was to develop a drug-drug interaction database (SFINX) to be integrated into decision support systems or to be used in website solutions for clinical evaluation of interactions.


Key elements such as substance properties and names, drug formulations, text structures and references were defined before development of the database. Standard operating procedures for literature searches, text writing rules and a classification system for clinical relevance and documentation level were determined. ATC codes, CAS numbers and country-specific codes for substances were identified and quality assured to ensure safe integration of SFINX into other data systems. Much effort was put into giving short and practical advice regarding clinically relevant drug-drug interactions.


SFINX includes over 8,000 interaction pairs and is integrated into Swedish and Finnish computerised decision support systems. Over 31,000 physicians and pharmacists are receiving interaction alerts through SFINX. User feedback is collected for continuous improvement of the content.


SFINX is a potentially valuable tool delivering instant information on drug interactions during prescribing and dispensing.


Drug-drug interaction database Clinical decision support system Drug interactions 



The Finnish Ministry of Health and Social Affairs, the Stockholm County Council and Karolinska Institutet, Stockholm, Sweden, for financial support.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ylva Böttiger
    • 5
  • Kari Laine
    • 2
    • 3
    • 4
  • Marine L. Andersson
    • 5
  • Tuomas Korhonen
    • 2
    • 3
    • 4
  • Björn Molin
    • 1
  • Marie-Louise Ovesjö
    • 5
  • Tuire Tirkkonen
    • 2
    • 3
    • 4
  • Anders Rane
    • 5
  • Lars L. Gustafsson
    • 1
    • 5
  • Birgit Eiermann
    • 1
    Email author
  1. 1.Department of Drug Management and InformaticsStockholm County CouncilStockholmSweden
  2. 2.medbase Ltd.TurkuFinland
  3. 3.Department of Pharmacology, Drug Development and TherapeuticsUniversity of TurkuTurkuFinland
  4. 4.Unit of Clinical PharmacologyTYKSLABTurkuFinland
  5. 5.Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska InstitutetKarolinska University HospitalStockholmSweden

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