Tramadol withdrawal in a neonate after long-term analgesic treatment of the mother
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Tramadol is frequently used in treatment of intermediate to severe pain. As it has a low affinity for opioid receptors it is considered a substance with lower risk for development of drug abuse, dependance or withdrawal syndrome. Among adults tramadol withdrawal after long-term treatment is reported occasionally [1, 5].
We treated the infant of a mother who suffered from chronic low back pain. As long-term analgesic treatment she received tramadol 400 mg/day. During the last weeks of pregnancy, the tramadol dose was reduced to 200 mg/day. Because of gestational diabetes and fetal macrosomia, caesarian section was performed at 36 weeks of gestational age. Birth weight was 4060 g (279 g >P97), length was 52 cm (P85), and head circumference was 37 cm (0.4 cm >P97). Apgar score was 9-10–10 at 1, 5 and 10 min. There were no signs of diabetic fetopathy.
On the second day of life, at 35 h of age the infant showed signs of severe withdrawal syndrome with high-pitched...
KeywordsTramadol Newborn Withdrawal syndrome
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