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European Journal of Clinical Pharmacology

, Volume 65, Issue 4, pp 429–430 | Cite as

Tramadol withdrawal in a neonate after long-term analgesic treatment of the mother

  • C. Willaschek
  • E. Wolter
  • R. Buchhorn
Letter to the Editors

Dear Sir,

Tramadol is frequently used in treatment of intermediate to severe pain. As it has a low affinity for opioid receptors it is considered a substance with lower risk for development of drug abuse, dependance or withdrawal syndrome. Among adults tramadol withdrawal after long-term treatment is reported occasionally [1, 5].

Case report

We treated the infant of a mother who suffered from chronic low back pain. As long-term analgesic treatment she received tramadol 400 mg/day. During the last weeks of pregnancy, the tramadol dose was reduced to 200 mg/day. Because of gestational diabetes and fetal macrosomia, caesarian section was performed at 36 weeks of gestational age. Birth weight was 4060 g (279 g >P97), length was 52 cm (P85), and head circumference was 37 cm (0.4 cm >P97). Apgar score was 9-10–10 at 1, 5 and 10 min. There were no signs of diabetic fetopathy.

On the second day of life, at 35 h of age the infant showed signs of severe withdrawal syndrome with high-pitched...

Keywords

Tramadol Newborn Withdrawal syndrome 

References

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Klinik für Kinder- und JugendmedizinCaritaskrankenhausBad MergentheimGermany
  2. 2.Klinik für Anästhesiologie und IntensivmedizinCaritaskrankenhausBad MergentheimGermany

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