Therapeutic traditions, patient socioeconomic characteristics and physicians’ early new drug prescribing–a multilevel analysis of rosuvastatin prescription in south Sweden

Special Article

DOI: 10.1007/s00228-008-0569-4

Cite this article as:
Ohlsson, H., Chaix, B. & Merlo, J. Eur J Clin Pharmacol (2009) 65: 141. doi:10.1007/s00228-008-0569-4



To investigate the role that both patient and outpatient factors related to health care practice (HCP) play in physicians’ early adoption of rosuvastatin.

Materials and methods

Generalized estimation equations (GEEs) and alternating logistic regression (ALR) with pair-wise odds ratios (PWORs) were used to measure similarities in rosuvastatin prescription within HCPs for all individuals with statin prescriptions in Skåne region, Sweden.


After 12 months, 53% of the HCPs had adopted the new statin. Rosuvastatin prescriptions co-occured within certain HCPs 3.56 times more often than one would have expected based on a random distribution. Private HCPs had four times higher probability of prescribing rosuvastatin than public HCPs.


Contextual characteristics of the HCP seem to be relevant for understanding physicians’ motivation to adopt rosuvastatin. Moreover, our study reveals inequity in health care as the socioeconomic status of the patients appears to influence the prescribing behavior of the physicians irrespective of medical reasons.


Therapeutic traditions Alternating logistic regression Early adopter Rosuvastatin 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Social Epidemiology, Department of Clinical Sciences in Malmö, Faculty of MedicineLund UniversityMalmöSweden
  2. 2.Department of Social MedicineSkåne RegionMalmöSweden
  3. 3.UMR-S 707 InsermUniversité Pierre et Marie Curie-Paris 6, Faculté de MédecineParisFrance
  4. 4.Social Epidemiology, Department of Clinical Sciences, Faculty of MedicineLund UniversityMalmöSweden

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