European Journal of Clinical Pharmacology

, Volume 64, Issue 6, pp 627–634

Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction

  • Alejandro Macchia
  • Simona Monte
  • Fabio Pellegrini
  • Marilena Romero
  • Daniel Ferrante
  • Hernán Doval
  • Antonio D’Ettorre
  • Aldo Pietro Maggioni
  • Gianni Tognoni
Pharmacoepidemiology and Prescription

DOI: 10.1007/s00228-008-0464-z

Cite this article as:
Macchia, A., Monte, S., Pellegrini, F. et al. Eur J Clin Pharmacol (2008) 64: 627. doi:10.1007/s00228-008-0464-z

Abstract

Purpose

Current strategies for avoiding atrial fibrillation (AF) are of limited value. We aim to assess the relationship between omega-3 fatty acids (n-3 PUFA) and AF occurrence in post-myocardial infarction (MI) patients.

Methods

A population study, linking hospital discharge records, prescription databases, and vital statistics, was conducted and included all consecutive patients with MI (ICD-9: 410) in six Italian local health authorities over a 3-year period. A propensity score (PS)-based, 5-to-1, greedy 1:1 matching algorithm was used to check consistency of results. Sensitivity analysis was performed to assess the robustness of findings.

Results

N-3 PUFA reduced the relative risk of the hospitalization for AF [hazard ratio (HR) 0.19, 95% CI 0.07–0.51] and was associated with a further and complementary reduction in all-cause mortality (HR 0.15, 95% CI 0.05–0.46). PS-based matched analysis and sensitivity analysis confirmed the main results.

Conclusion

n-3 PUFA reduced both all-cause mortality and incidence of 1-year AF in patients hospitalized with MI.

Keywords

Fatty acids Epidemiology Atrial fibrillation Myocardial infarction Nutrition 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Alejandro Macchia
    • 1
    • 4
  • Simona Monte
    • 1
  • Fabio Pellegrini
    • 1
  • Marilena Romero
    • 1
  • Daniel Ferrante
    • 2
  • Hernán Doval
    • 2
  • Antonio D’Ettorre
    • 1
  • Aldo Pietro Maggioni
    • 3
  • Gianni Tognoni
    • 1
  1. 1.Department of Clinical Pharmacology and EpidemiologySanta Maria ImbaroItaly
  2. 2.GESICA FoundationBuenos AiresArgentina
  3. 3.Centro Studi ANMCOFirenzeItaly
  4. 4.Department of Clinical Pharmacology and Epidemiology, Laboratory of PharmacoepidemiologyConsorzio Mario Negri SudSanta Maria ImbaroItaly

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