Factors associated with adherence to drug therapy: a population-based study
- 263 Downloads
To investigate adherence to prescription in a female population aged 35–65 years.
Postal questionnaire study of 2991 randomly sampled 35- to 64-year-old women in seven provinces of central Sweden.
The study was performed in 1995 as a cross-sectional postal questionnaire study in seven counties in central Sweden. The questionnaire was sent to a random sample of 4200 women between the ages of 35 and 64, of whom 2991 (71.2%) responded. The questionnaire asked about drugs prescribed during the past year and about factors potentially affecting adherence.
The same women had different degrees of adherence to different medications. A large number of factors were associated with adherence. Multivariate analysis revealed that age, scheduled check-up, perceived importance of medication, concerns about medication safety and taking medication for a respiratory or a cardiovascular disease were significantly related to adherence. Adherence ranged from 15–98% depending on these factors, and was the lowest among young women who regarded their medication as unimportant and who had no scheduled check-up; the highest reported adherence was found among elderly women who regarded their medication as important and who had a scheduled check-up.
Factors that were associated with the perceived importance of medication had a positive effect on adherence, while concerns about medication safety had a negative effect.
KeywordsAdherence Communication skills Epidemiology Prescription Women
This study was supported by grants from The Swedish Foundation for Health Care Sciences and Allergy Research, from the Epidemiology Department of AstraZeneca R&D Mölndal and from Uppsala University.
- 12.Harlow SD, Linet MS (1989) Agreement between questionnaire data and medical records. The evidence for accuracy of recall. Am J Epidemiol 129:223–248Google Scholar
- 18.JMP User’s guide (2000) SAS Institute Cary, N.C.Google Scholar
- 21.Lindgren R, Berg G, Hammar M, Zuccon E (1993) Hormonal replacement therapy and sexuality in a population of Swedish postmenopausal women. Acta Obst Gynecol Scand 72:292–297Google Scholar
- 24.Popa-Lisseanu MGG, Greisinger A, Richardson M, O’Malley KJ, Janssen NM, Marcus DM, Tagore J, Suarez-Almazor M (2005) Determinants of treatment. Adherence in ethnically diverse, economically disadvantaged patients with rheumatic disease. J Rheumatol 32:913–928Google Scholar
- 26.Roter DL (1989) Which facets of communication have strong effect on outcome – a meta-analysis. In: Stewart MA, Roter DL (eds) Communication with medical patients. Sage Publ, Newbury ParkGoogle Scholar
- 30.Sidel J, Ryan K, Nemis-White J (1998) Shaping the healthcare environment through evidence-based medicine: A case study of the ICONS project. Hosp Quart 2:29–33Google Scholar
- 31.Statistical Analysis System (1995) Statistical Analysis System. SAS Institute, Cary, N.C.Google Scholar
- 33.Tibblin G, Tibblin B, Peciva S, Kullman S, Svärdsudd K (1990) The Göteborg Quality of Life Instrument-an assessement of well-being and symptoms among men born in 1913 and 1923, methods and validity. Scand J Prim Health Care Suppl 1:33–38Google Scholar
- 34.Wahl C, Gregoire JP, Teo K, Beaulieu M, Labelle S, Leduc B, Cochrane B, Lapointe L, Montague T (2005) Concordance, compliance and adherence in healthcare: closing gaps and improving outcomes. Healthcare Q 8:65–70Google Scholar
- 35.Van den Brandt PA, Petri H, Dorant E, Goldbohm RA, Van de Crommert S (1991) Comparison of questionnaire information and pharmacy data on drug use. Pharm Weekblad 13:91–96Google Scholar